[Erythrocyte alteration in long standing labor inhibition with a beta-sympathicomimetic drug (Partusisten) (author's transl)].

The relative flow rate of the red blood cells in a hematocrit of 10% was measured with a 5 mu nuclepore filter system. The influence of Partusisten was determined by the alteration of the red blood cells. The in vitro concentration of 0.1 ng Partusisten/ml blood resulted in a relative improvement of the flow rate, which we also found in normal pregnancies. However, in a vivo concentration of 4 microgram intravenous Partusisten/min for 48 h, the red cell alteration properties decreased. After a greater time interval, the red blood cells alteration was about the same as in the pre-drug level. The uteroplacental perfusion changed in dependence to the concentration of the beta-mimetic drug (Partusisten). The presence of rigid red blood cells can be first seen in the microcirculation impairment. Depending on the concentration of Partusisten, a protective effect on the flow properties of the red blood cells could be achieved, which altered during pregnancy. However, in late gestosis, a lower dosage should be administered than in labor inhibition.