Literature DB >> 7364973

Capillary alterations in scleroderma.

R Fleischmajer, J S Perlish.   

Abstract

Electron microscopy of capillaries was performed in scleroderma skin. The main alterations were (1) gaps, vacuolization and eventual destruction of endothelial cells, (2) reduplication of the basal lamina, (3) perivascular cellular infiltrates consisting of lymphocytes, plasma cells, macrophages, or monocytes, and (4) fibroblasts and pericytes with enlarged, rough endoplasmic reticulum (RER) accompanied by perivascular fibrosis. Perivascular cellular infiltrates and endothelial cell damage appear to precede the stage of fibrosis.

Entities:  

Mesh：

Year:  1980        PMID： 7364973     DOI： 10.1016/s0190-9622(80)80396-3

Source DB:  PubMed          Journal:  J Am Acad Dermatol        ISSN： 0190-9622            Impact factor:   11.527


  24 in total

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Review 8.  Molecular and cellular basis of scleroderma.

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9.  Histomorphometrical analysis of microvascular abnormalities in connective tissue diseases.

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Review 10.  Vascular disease in scleroderma.

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