Literature DB >> 7363941

Selective blockade of neurotensin-induced coronary vessel constriction in perfused rat hearts by a neurotensin analogue.

R Quirion, F Rioux, D Regoli, S St-Pierre.   

Abstract

[D-Trp11]-NT, an analogue of neurotensin (NT) in which Tyr11 was replaced with D-Trp, was found to antagonize selectively NT-induced coronary vessel constriction in perfused rat hearts, in concentrations varying between 1.3 x 10(-7) and 1.1 x 10(-6) M. Higher concentrations of [D-Trp11]-NT displayed NT-like activity. In rat stomach strips and guinea pig atria, [D-Trp11]-NT exhibits full intrinsic activity, markedly reduced affinity for NT receptors, but no inhibitory effect against NT. These results suggest that the receptors mediating the constrictor action of NT in the coronary vessels of rat hearts are pharmacologically distinct from those subserving the stimulant effects of NT in rat stomach strips and guinea pig atria.

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Year:  1980        PMID： 7363941     DOI： 10.1016/0014-2999(80)90133-8

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Neurotensin and acetylcholine evoke common responses in frog oocytes injected with rat brain messenger ribonucleic acid.

Authors:  C Hirono; I Ito; H Sugiyama
Journal:  J Physiol       Date:  1987-01       Impact factor: 5.182

Review 2.  The role of neuropeptides in adverse myocardial remodeling and heart failure.

Authors:  Alexander Widiapradja; Prasad Chunduri; Scott P Levick
Journal:  Cell Mol Life Sci       Date:  2017-01-17       Impact factor: 9.261

3.  Structure-antinociceptive activity studies with neurotensin.

Authors:  S Furuta; K Kisara; S Sakurada; T Sakurada; Y Sasaki; K Suzuki
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739

4.  Inhibition of neurotensin (NT)-induced glucagon release by [D-Trp11]-NT1.

Authors:  M Ukai; T Itatsu; A Shibata; F Rioux; S St-Pierre
Journal:  Experientia       Date:  1982-10-15

Review 5.  Stress triggers coronary mast cells leading to cardiac events.

Authors:  Michail Alevizos; Anna Karagkouni; Smaro Panagiotidou; Magdalini Vasiadi; Theoharis C Theoharides
Journal:  Ann Allergy Asthma Immunol       Date:  2013-10-10       Impact factor: 6.347

6.  Membrane potential and current responses to neurotensin in the longitudinal muscle of the rectum of the fowl.

Authors:  S Komori; T Matsuoka; S C Kwon; T Takewaki; H Ohashi
Journal:  Br J Pharmacol       Date:  1992-11       Impact factor: 8.739
  6 in total

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