The effect of propranolol on human psychomotor performance.

Despite their widespread usage the effect of beta blockers on human performance has been only sparsely studied and results of investigations are discrepant. This study examines the effect of one of the most commonly prescribed beta adrenergic blocking drugs, propranolol, on psychomotor function. To demonstrate the sensitivity of the test method and to provide some basis for comparison, the effect of small doses of sodium amylobarbitone on psychomotor performance is also measured. Results indicate that propranolol in a single dose of 40 mg produces a small but significant decrement of performance, an effect comparable to that of 25 mg of sodium amylobarbitone. Habituation to chronic administration of propranolol at a daily dose level of 120 mg is also apparent. The clinical significance of these effects, particularly in aviation medicine, is discussed.