Literature DB >> 7362203

Estimating genetic correlations.

C A Smith.   

Abstract

A method is proposed for simultaneous estimation of genetical variance and covariance components for quantitative characters and hence correlations and cross-correlations between relatives. It proceeds by successive approximations, which are not difficult to compute. Judging by examples, they appear to converge rapidly in practice. When distributions are normal and homoscedastic, the method gives the maximum-likelihood estimates and their error variances and covariances. It can be readily modified to take into account assumptions such as that means and variances are equal in fathers and sons. But the amount of calculations required goes up very rapidly with the number of characters and relatives considered stimultaneously.

Mesh:

Year:  1980        PMID: 7362203     DOI: 10.1111/j.1469-1809.1980.tb01560.x

Source DB:  PubMed          Journal:  Ann Hum Genet        ISSN: 0003-4800            Impact factor:   1.670


  3 in total

1.  Assessing familial aggregation of age at onset, by using estimating equations, with application to breast cancer.

Authors:  L Hsu; L P Zhao
Journal:  Am J Hum Genet       Date:  1996-05       Impact factor: 11.025

2.  Sibling and parent--offspring correlation estimation with variable family size.

Authors:  S Karlin; E C Cameron; P T Williams
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

3.  A method for assessing patterns of familial resemblance in complex human pedigrees, with an application to the nevus-count data in Utah kindreds.

Authors:  L P Zhao; J Grove; F Quiaoit
Journal:  Am J Hum Genet       Date:  1992-07       Impact factor: 11.025

  3 in total

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