Literature DB >> 7360486

An evaluation of two schedules of VP-16 and adriamycin in patients with advanced breast cancer.

J Rubin, D A Decker, D L Ahmann, R T Eagan, J N Ingle, R G Hahn.   

Abstract

A phase II study utilizing VP-16 and adriamycin in a randomized fashion tested the concept of synchronization of the drugs in treatment of metastatic breast cancer. Although there was a trend in median survival following the synchronized schedule, there was no significant difference in survival or progression-free intervals. The concept of synchronization was not established.

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Year:  1980        PMID: 7360486     DOI: 10.1159/000225424

Source DB:  PubMed          Journal:  Oncology        ISSN: 0030-2414            Impact factor:   2.935


  3 in total

Review 1.  Etoposide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in combination chemotherapy of cancer.

Authors:  J M Henwood; R N Brogden
Journal:  Drugs       Date:  1990-03       Impact factor: 9.546

2.  Adriamycin and VP16-213 combination treatment for breast cancer previously treated by the CMF regimen.

Authors:  G Perez Manga; P Madrigal Alonso; H Alburquerque Carbuccia
Journal:  Cancer Chemother Pharmacol       Date:  1982       Impact factor: 3.333

Review 3.  Different dosage schedules for reducing cardiotoxicity in people with cancer receiving anthracycline chemotherapy.

Authors:  Elvira C van Dalen; Helena J H van der Pal; Leontien C M Kremer
Journal:  Cochrane Database Syst Rev       Date:  2016-03-03
  3 in total

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