| Literature DB >> 736016 |
T M O'Dorisio, J T Spaeth, E W Martin, K R Sirinek, N R Thomford, E L Mazzaferri, S Cataland.
Abstract
Serum gastric inhibitory polypeptide was measured in dogs prepared with Heidenhain pouches and Mann-Bollman fistulae following the intraduodenal (ID) infusion of isotonic saline, 20% glucose, or 20% mannitol. Following ID 20% glucose, serum GIP concentrations rose significantly (P less than 0.05) between 30 and 120 min and there was a significant inhibition (P less than 0.05) of acid secretion in the Heidenhain pouches between 15 and 75 min. A good correlation (r = 0.925) was found between the rise in serum GIP and the inhibition of acid secretion. Although neither ID isotonic saline nor 20% mannitol stimulated GIP release, the latter produced a significant (P less than 0.05) inhibition of acid secretion between 60 and 105 min. We conclude: (1) the inhibitory effect of acid secretion following ID glucose is mediated in part by the release of endogenous GIP; (2) glucose and mannitol probably inhibit gastric acid secretion by different mechanisms.Entities:
Mesh：
Substances：
Year: 1978 PMID： 736016 DOI： 10.1007/bf01072882
Source DB: PubMed Journal: Am J Dig Dis ISSN： 0002-9211