Literature DB >> 7360141

Increased sensitivity of cell strains from Cockayne's syndrome to sister-chromatid-exchange induction and cell killing by UV light.

R R Marshall, C F Arlett, S A Harcourt, B A Broughton.   

Abstract

Ultraviolet light-induced sister-chromatid exchanges (SCE) and cell killing were investigated in 4 fibroblast cell strains from patients with the sun-sensitive disease Cockayne's syndrome (CS). All 4 CS cell strains proved to be hypersensitive to UV for both of these end-points, but no close correlation between levels of SCE and lethality was observed. Cell strains from two individuals heterozygous for CS were indistinguishable from wild-type.

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Year:  1980        PMID： 7360141     DOI： 10.1016/0027-5107(80)90180-3

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  10 in total

1.  Cells from an immunodeficient patient (46BR) with a defect in DNA ligation are hypomutable but hypersensitive to the induction of sister chromatid exchanges.

Authors:  L M Henderson; C F Arlett; S A Harcourt; A R Lehmann; B C Broughton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-04       Impact factor: 11.205

2.  Ultraviolet light-induced chromosomal aberrations in cultured cells from Cockayne syndrome and complementation group C xeroderma pigmentosum patients: lack of correlation with cancer susceptibility.

Authors:  L R Seguin; R E Tarone; K H Liao; J H Robbins
Journal:  Am J Hum Genet       Date:  1988-03       Impact factor: 11.025

3.  Protein oxidative damage is associated with life expectancy of houseflies.

Authors:  R S Sohal; S Agarwal; A Dubey; W C Orr
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

Review 4.  Sister chromatid exchange (SCE) and structural chromosome aberration in mutagenicity testing.

Authors:  E Gebhart
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

Review 5.  Dna repair: pathways and defects.

Authors:  C R Bartram
Journal:  Eur J Pediatr       Date:  1980-12       Impact factor: 3.183

6.  A clinical study of a family with Cockayne's syndrome.

Authors:  R Proops; A M Taylor; J Insley
Journal:  J Med Genet       Date:  1981-08       Impact factor: 6.318

7.  Clinical and biochemical studies in three patients with severe early infantile Cockayne syndrome.

Authors:  J Jaeken; H Klocker; H Schwaiger; R Bellmann; M Hirsch-Kauffmann; M Schweiger
Journal:  Hum Genet       Date:  1989-11       Impact factor: 4.132

8.  Ultraviolet-induced mutations in Cockayne syndrome cells are primarily caused by cyclobutane dimer photoproducts while repair of other photoproducts is normal.

Authors:  C N Parris; K H Kraemer
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205

9.  The ultraviolet sensitivity of Cockayne syndrome cells is not a consequence of reduced cellular NAD content.

Authors:  L V Mayne; B C Broughton; A R Lehmann
Journal:  Am J Hum Genet       Date:  1984-03       Impact factor: 11.025

10.  Cockayne syndrome group B protein has novel strand annealing and exchange activities.

Authors:  Meltem Muftuoglu; Sudha Sharma; Tina Thorslund; Tinna Stevnsner; Martin M Soerensen; Robert M Brosh; Vilhelm A Bohr
Journal:  Nucleic Acids Res       Date:  2006-01-12       Impact factor: 16.971
  10 in total

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