| Literature DB >> 7359516 |
G Y Paris, D L Garmaise, D G Cimon, L Swett, G W Carter, P Young.
Abstract
A series of 1,3-dialkanoyl-2-(2-methyl-4-oxo-1,3-benzodioxan-2-yl)glycerides ("cyclic aspirin triglycerides") was synthesized. They demonstrated essentially all the systemic antiinflammatory activity associated with aspirin in the carrageenin-induced rat paw edema test. Examination of the rat stomachs showed that the 1,3-didecanoyl derivative did not cause gastric lesions.Entities:
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Year: 1980 PMID： 7359516 DOI： 10.1021/jm00175a015
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446