Literature DB >> 7358813

Determination of clonidine in human plasma by glass capillary gas chromatography with electron-capture detection.

P O Edlund.   

Abstract

A gas chromatography assay for clonidine in human plasma has been developed. The buffered serum is extracted on silica columns, alkylated with pentafluorobenzyl bromide, cleaned up-by extractions and analysed by glass capillary gas chromatography with falling-glass-needle injection and electron-capture detection. A gas chromatographic-mass spectrometric analysis of the derivatives formed and an investigation of the structure dependence of the electron-capture response are presented.

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Year:  1980        PMID: 7358813     DOI: 10.1016/s0021-9673(00)87882-6

Source DB:  PubMed          Journal:  J Chromatogr


  4 in total

1.  New aspects in the metabolism of alinidine in man.

Authors:  D Arndts; H J Forster
Journal:  Eur J Drug Metab Pharmacokinet       Date:  1981       Impact factor: 2.441

2.  Clonidine kinetics in man--evidence for dose dependency and changed pharmacokinetics during chronic therapy.

Authors:  M Frisk-Holmberg; L Paalzow; P O Edlund
Journal:  Br J Clin Pharmacol       Date:  1981-11       Impact factor: 4.335

3.  Relationship between the cardiovascular effects and steady-state kinetics of clonidine in hypertension. Demonstration of a therapeutic window in man.

Authors:  M Frisk-Holmberg; L Paalzow; L Wibell
Journal:  Eur J Clin Pharmacol       Date:  1984       Impact factor: 2.953

Review 4.  Clinical pharmacokinetics of clonidine.

Authors:  D T Lowenthal; K M Matzek; T R MacGregor
Journal:  Clin Pharmacokinet       Date:  1988-05       Impact factor: 6.447

  4 in total

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