Literature DB >> 7358771

Mammary tumorigenic effect of a new nitrosourea, 1,3-dibutyl-l-nitrosourea (B-BNU), in female Donryu rats.

T Ogiu, T Kajiwara, K Furuta, M Takeuchi, S Odashima, K Tada.   

Abstract

Four groups (groups 1-4) of female Donryu rats were given continuously 400, 200, 100, or 0 ppm solution of 1,3-dibutyl-l-nitrosourea (B-BNU) as their drinking water, and were studied for the development of tumors. The incidence of mammary tumors was 15/19 (79%), 20/24 (83%), 21/26 (81%), and 8/25 (32%) in groups 1, 2, 3, and 4, respectively. In addition, hematopoietic neoplasms, uterine tumors, and vaginal tumors developed in 13, 11, and six rats, respectively in 69 treated rats. Other tumors were infrequent.

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Year:  1980        PMID： 7358771     DOI： 10.1007/bf00412895

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  14 in total

1.  Mammary cancer induced by a single feeding of polymucular hydrocarbons, and its suppression.

Authors:  C HUGGINS; L C GRAND; F P BRILLANTES
Journal:  Nature       Date:  1961-01-21       Impact factor: 49.962

2.  [Carcinogenic action of n-butylnitrosourea in adult Sprague-Dawley-rats by special consideration of its leukemogenic action after its chronic application in drinking water (author's transl)].

Authors:  D Gonsior; W J Zeller; S Ivankovic; D Schmähl
Journal:  Arch Geschwulstforsch       Date:  1974

3.  Effect of actinomycin-d and mitomycin-c on induction of rat mammary cancer with 7, 12-dimethylbenz (alpha) anthracene.

Authors:  T Tominaga; T Taguchi; S Shiba
Journal:  Gan       Date:  1973-06

4.  Effect of increasing doses of estrogen and progesterone on mammary carcinogenesis in the rat.

Authors:  G M McCormick; R C Moon
Journal:  Eur J Cancer       Date:  1973-07       Impact factor: 9.162

5.  Hormonal implication in initiation and progression of experimental mammary tumors in the rat.

Authors:  S Takizawa
Journal:  Acta Pathol Jpn       Date:  1973-11

6.  Alterations in DMBA-induced rat mammary tumors by actinomycin D.

Authors:  H A Gardner; J A Kellen; K M Anderson
Journal:  J Natl Cancer Inst       Date:  1973-04       Impact factor: 13.506

7.  Role of ovarian hormones in mammary tumorigenesis by a continuous oral administration of N-nitrosobutylurea in Wistar-Furth rats.

Authors:  S Takizawa; T Yamasaki
Journal:  Gan       Date:  1971-12

8.  Induction of tumors in the stomach and nervous system of the ACI/N rat by continuous oral administration of 1-methyl-3-acetyl-1-nitrosourea.

Authors:  A Maekawa; S Odashima; M Nakadate
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-06-15

9.  Induction of tumors of peripheral nervous system in female Donryu rats by continuous oral administration of 1-methyl-1-nitrosourea.

Authors:  T Ogiu; M Nakadate; K Furuta; A Maekawa; S Odashima
Journal:  Gan       Date:  1977-08

10.  Induction of Leukemias and digestive tract tumors in Donryu rats by 1-propyl-1-nitrosourea.

Authors:  T Ogiu; M Nakadate; S Odashima
Journal:  J Natl Cancer Inst       Date:  1975-04       Impact factor: 13.506
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  2 in total

1.  Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Authors:  A Maekawa; H Onodera; H Tanigawa; K Furuta; J Kanno; T Ogiu; Y Hayashi
Journal:  Environ Health Perspect       Date:  1987-08       Impact factor: 9.031

2.  A carcinogenic potency database of the standardized results of animal bioassays.

Authors:  L S Gold; C B Sawyer; R Magaw; G M Backman; M de Veciana; R Levinson; N K Hooper; W R Havender; L Bernstein; R Peto
Journal:  Environ Health Perspect       Date:  1984-12       Impact factor: 9.031
  2 in total

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