Literature DB >> 7358394

The presence of androgen-binding receptors in genital and nongenital skin fibroblasts.

J Herfert, T F Wienker, H H Ropers.   

Abstract

The specific, receptor-dependent 5 alpha-dihydrotestosterone-binding capacity of cultured fibroblasts derived from genital and nongenital skin has been compared. With the methods employed, the detectable amount of the DHT receptor in nongenital skin-derived fibroblasts is variable, often approaching the limit of detectability. Therefore it is concluded that for differential diagnosis of disorders of sexual development, DHT-binding studies should be performed with genital skin fibroblasts only.

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Year:  1980        PMID： 7358394     DOI： 10.1007/bf00273510

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  19 in total

1.  Locus on human X chromosome for dihydrotestosterone receptor and androgen insensitivity.

Authors:  W J Meyer; B R Migeon; C J Migeon
Journal:  Proc Natl Acad Sci U S A       Date:  1975-04       Impact factor: 11.205

2.  Androgen receptor in human skin fibroblasts. Characterization of a specific 17beta-hydroxy-5alpha-androstan-3-one-protein complex in cell sonicates and nuclei.

Authors:  B S Keenan; W J Meyer; A J Hadjian; C J Migeon
Journal:  Steroids       Date:  1975-04       Impact factor: 2.668

3.  Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.

Authors:  P C Walsh; J D Madden; M J Harrod; J L Goldstein; P C MacDonald; J D Wilson
Journal:  N Engl J Med       Date:  1974-10-31       Impact factor: 91.245

4.  Letter: Skin biopsy site and biology of fibroblast strains.

Authors:  M Kaufman; L Pinsky
Journal:  Lancet       Date:  1973-11-24       Impact factor: 79.321

5.  Syndrome of androgen insensitivity in man: absence of 5 alpha-dihydrotestosterone binding protein in skin fibroblasts.

Authors:  B S Keenan; W J Meyer; A J Hadjian; H W Jones; C J Migeon
Journal:  J Clin Endocrinol Metab       Date:  1974-06       Impact factor: 5.958

6.  X-linked gene for testicular feminization in the mouse.

Authors:  M F Lyon; S G Hawkes
Journal:  Nature       Date:  1970-09-19       Impact factor: 49.962

7.  Androgen insensitivity in man: evidence for genetic heterogeneity.

Authors:  J A Amrhein; W J Meyer; H W Jones; C J Migeon
Journal:  Proc Natl Acad Sci U S A       Date:  1976-03       Impact factor: 11.205

8.  Studies on steroid hormone receptors (5alpha-dihidrotesterone, estradiol, and dexamethasone) in cultured human fibroblasts and amniotic fluid cells.

Authors:  T Bauknecht
Journal:  Hum Genet       Date:  1977-12-23       Impact factor: 4.132

9.  5alpha-reductase activity of genital and nongenital skin fibroblasts from patients with 5alpha-reductase deficiency, androgen insensitivity, or unknown forms of male pseudohermaphroditism.

Authors:  L Pinsky; M Kaufman; C Straisfeld; B Zilahi; C S Hall
Journal:  Am J Med Genet       Date:  1978

10.  Male pseudohermaphroditism presumably due to target organ unresponsiveness to androgens. Deficient 5alpha-dihydrotestosterone binding in cultured skin fibroblasts.

Authors:  M Kaufman; C Straisfeld; L Pinsky
Journal:  J Clin Invest       Date:  1976-08       Impact factor: 14.808
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  2 in total

1.  DHT-receptor in cultured human fibroblasts: binding study in a family with androgen insensitivity (complete testicular feminisation).

Authors:  E Donti; I Nicoletti; P Filipponi; G Venti; V Bocchini; F Santeusanio
Journal:  J Med Genet       Date:  1982-10       Impact factor: 6.318

2.  Carrier detection in the testicular feminisation syndrome: deficient 5 alpha-dihydrotestosterone binding in cultured skin fibroblasts from the mothers of patients with complete androgen insensitivity.

Authors:  M B Hodgins; E M Duke; D Ring
Journal:  J Med Genet       Date:  1984-06       Impact factor: 6.318
  2 in total

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