Favorable outcome of central nervous system toxoplasmosis occurring in a patient with untreated Hodgkin's disease.

The current report describes severe, multi-focal central nervous system (CNS) toxoplasmosis in a patient with untreated Hodgkin's disease. Anti-toxoplasma therapy was associated with prompt clinical improvement, and as such may represent the first successfully treated case of global CNS-toxoplasmosis occurring in a person with histologically documented lymphoma. Previously, CNS-toxoplasmosis has been noted to complicate lymphomas after initiation of anti-neoplastic therapy. The occurrence of disseminated toxoplasmosis prior to anti-neoplastic therapy is unique and suggests that lymphoma per se is a predisposing factor.