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Literature DB >> 7355426

Reduction in regional cerebral blood flow during normal aging in man.

E Melamed, S Lavy, S Bentin, G Cooper, Y Rinot.

Abstract

Regional cerebral blood flow (rCBF) was measured by the 133Xenon inhalation method in a selected group of 44 normal non-hospitalized, normotensive subjects aged 19 to 79 years. rCBF was computed as the initial slope index value (ISI). Advancing age was associated with significant reductions in the mean brain and mean hemispheric ISI as well as in individual ISI levels measured from all areas in both hemispheres. Our findings suggest that decline of rCBF is not limited to normal elderly subjects but that it is a progressive phenomenon which begins at an earlier age.

Entities: Chemical Gene Species

Mesh：

Substances：
Xenon Radioisotopes

Year: 1980 PMID： 7355426 DOI： 10.1161/01.str.11.1.31

Source DB: PubMed Journal: Stroke ISSN： 0039-2499 Impact factor: 7.914

Keyword Cloud
Cited

40 in total

1. Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats.

Authors: T P Wong; G Marchese; M A Casu; A Ribeiro-da-Silva; A C Cuello; Y De Koninck
Journal: J Neurosci Date: 2000-11-15 Impact factor: 6.167

2. A quantitative approach to technetium-99m hexamethylpropylene amine oxime.

Authors: H Matsuda; S Tsuji; N Shuke; H Sumiya; N Tonami; K Hisada
Journal: Eur J Nucl Med Date: 1992

3. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.

Authors: Han Yan; Matthew Mitschelen; Georgina V Bixler; Robert M Brucklacher; Julie A Farley; Song Han; Willard M Freeman; William E Sonntag
Journal: J Endocrinol Date: 2011-07-12 Impact factor: 4.286

4. Regional cerebral blood flow asymmetries in a group of 189 normal subjects at rest.

Authors: G Rodriguez; R Coppola; F De Carli; S Francione; S Marenco; F Nobili; J Risberg; G Rosadini; S Warkentin
Journal: Brain Topogr Date: 1991 Impact factor: 3.020

5. Nuclear medicine-epitomes of progress: regional cerebral blood flow.

Authors: N Milne; K P Lyons
Journal: West J Med Date: 1981-05

6. Metabolic syndrome and cognitive decline among the oldest old in Okinawa: in search of a mechanism. The KOCOA Project.

Authors: Yuriko Katsumata; Hidemi Todoriki; Yasushi Higashiuesato; Shotoku Yasura; D Craig Willcox; Yusuke Ohya; Bradley J Willcox; Hiroko H Dodge
Journal: J Gerontol A Biol Sci Med Sci Date: 2011-10-20 Impact factor: 6.053

Reduction in regional cerebral blood flow during normal aging in man.

1. Loss of presynaptic and postsynaptic structures is accompanied by compensatory increase in action potential-dependent synaptic input to layer V neocortical pyramidal neurons in aged rats.

2. A quantitative approach to technetium-99m hexamethylpropylene amine oxime.

3. Circulating IGF1 regulates hippocampal IGF1 levels and brain gene expression during adolescence.

4. Regional cerebral blood flow asymmetries in a group of 189 normal subjects at rest.

5. Nuclear medicine-epitomes of progress: regional cerebral blood flow.

6. Metabolic syndrome and cognitive decline among the oldest old in Okinawa: in search of a mechanism. The KOCOA Project.

7. Development and Validation of the State-Trait Inventory of Cognitive Fatigue in Community-Dwelling Older Adults.

8. Cerebral circulation and oxygen metabolism in moyamoya disease of ischemic type in children.

9. The orbitofrontal cortex, real-world decision making, and normal aging.

10. Sex differences of human cortical blood flow and energy metabolism.