The influence of age on the hypothalamo-neurohypophyseal system of the mouse: a quantitative ultrastructural analysis of the supraoptic nucleus.

A quantitative study of various morphological parameters in endocrine cells of the neuroendocrine region of the laboratory mouse was carried out. The supraoptic nucleus of the hypothalamo-neurohypophyseal system synthesises the hormones vasopressin and, to a lesser extent, oxytocin, and transports them to the posterior pituitary. Female C57BL/Icrfat mice at 8 and 26 months of age, free of macroscopic pathology, were sampled when in a physiologically defined resting state. No significant differences in the volume fractions of most cell and subcellular components could be detected at the two ages studied; however, significant increases in the volume fractions of hormone-containing granules and lipofuscin (aging pigment) were demonstrated in older animals. These observations are similar to those made on rat endocrine pancreas also in the resting state. The notion that these hormone-secreting cells are "protected" to some extent from the aging process, and may have some of the qualities of "pace-maker" cells, is discussed.