Bilateral endogenous Aspergillus endophthalmitis.

A case of successfully treated Aspergillus endophthalmitis is presented. Treatment consisted of wide vitrectomy. At the end of surgery, 5 micrograms of amphoteracin B were injected into the center of the vitreous cavity, and an additional .75 mg was given subconjunctivally both at surgery and on the second postoperative day, at which time 2 mg of dexamethasone were also given subjunctivally. Systemic antifungal agents were not used. After 2 1/2 months, the second eye developed a similar metastatic infection from heart value vegetation. This case illustrates that use of wide vitrectomy and intravitreous antifungal agents alone can cure Aspergillus endophthalmitis and preserve useful vision.