Literature DB >> 734683

Effect of Di-(2-ethylhexyl) phthalate (DEHP) on chemical constituents and enzymatic activity of rat liver.

S P Srivastava, D K Agarwal, M Mushtaq, P K Seth.   

Abstract

Effect of Di(2-ethylhexyl) phthalate (DEHP), was investigated on chemical constituents and activity of certain enzymes of rat liver. A significant increase in liver weight; total and relative to body weight; decrease in total, free and esterified cholesterol; and no change in dry weight, moisture; RNA, DNA, total lipids, phospholipids, pyruvic acid and lactic acid contents was observed in liver of DEHP-treated rats as compared to controls. Activity of 3 mitochondrial enzymes, malic dehydrogenase, cytochrome-c-oxidase and diaphorase were significantly decreased while that of NADH-cytochrome c reductase, RNAase and DNAase remained unaltered upon treatment. The results suggest that DEHP exerts its hepatotoxic effects by interfering with bioenergetics of the cell.

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Year:  1978        PMID： 734683     DOI： 10.1016/s0300-483x(78)91639-6

Source DB:  PubMed          Journal:  Toxicology        ISSN： 0300-483X            Impact factor:   4.221


  6 in total

1.  Effect of phthalic acid esters on drug metabolizing enzymes.

Authors:  P K Seth; D K Agarwal; S Agarwal
Journal:  Bull Environ Contam Toxicol       Date:  1981-06       Impact factor: 2.151

2.  Phthalate esters. II. Effects of inhaled dibutylphthalate on cytochrome P-450 mediated metabolism in rat liver and lung.

Authors:  F Walseth; O G Nilsen
Journal:  Arch Toxicol       Date:  1984-07       Impact factor: 5.153

3.  Phthalate esters I: Effects on cytochrome P-450 mediated metabolism in rat liver and lung, serum enzymatic activities and serum protein levels.

Authors:  F Walseth; R Toftgård; O G Nilsen
Journal:  Arch Toxicol       Date:  1982-05       Impact factor: 5.153

4.  The effect of feeding Di-(2-ethylhexyl) phthalate (DEHP) on the lipid metabolism of laying hens.

Authors:  D L Wood; J Bitman
Journal:  Lipids       Date:  1980-03       Impact factor: 1.880

5.  Absorption, metabolism, and excretion of di(2-ethylhexyl) phthalate by rats and mice.

Authors:  P W Albro
Journal:  Environ Health Perspect       Date:  1986-03       Impact factor: 9.031

Review 6.  Hepatic effects of phthalate esters.

Authors:  P K Seth
Journal:  Environ Health Perspect       Date:  1982-11       Impact factor: 9.031
  6 in total

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