Literature DB >> 7345007

Inhibition of the hepatocarcinogenic activity of diethylnitrosamine (DENA) by ethanol in rats.

M Habs, D Schmähl.   

Abstract

Male Sprague-Dawley rats received 0.1 mg/kg of diethyl-nitrosamine orally five times a week for life with or without additional subsequent administration of 5 ml/rat/day of a 25% aqueous solution of ethanol. The additional treatment with ethanol significantly reduced the induction of liver cancer, but not of esophageal tumors. These findings do not support speculations based on epidemiologic studies as to a cancer-causing effect of alcohol.

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Year:  1981        PMID: 7345007

Source DB:  PubMed          Journal:  Hepatogastroenterology        ISSN: 0172-6390


  6 in total

1.  Long-term ethanol consumption promotes hepatic tumorigenesis but impairs normal hepatocyte proliferation in rats.

Authors:  Pollyanna R G Chavez; Fuzhi Lian; Jayong Chung; Chun Liu; Sergio A R Paiva; Helmut K Seitz; Xiang-Dong Wang
Journal:  J Nutr       Date:  2011-04-13       Impact factor: 4.798

Review 2.  Diet and cancer.

Authors:  M Habs; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1980-01       Impact factor: 4.553

3.  Effect of ethanol on microsomal metabolism of dimethylnitrosamine.

Authors:  M Schwarz; K E Appel; D Schrenk; W Kunz
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553

4.  Effect of chronic alcohol consumption on tumor incidence due to dimethylnitrosamine administration.

Authors:  R Teschke; M Minzlaff; H Oldiges; H Frenzel
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553

5.  Enhancing effect of ethanol on aflatoxin B1-induced hepatocarcinogenesis in male ACI/N rats.

Authors:  T Tanaka; A Nishikawa; H Iwata; Y Mori; A Hara; I Hirono; H Mori
Journal:  Jpn J Cancer Res       Date:  1989-06

6.  Cytochrome P-450 isozyme pattern is related to individual susceptibility to diethylnitrosamine-induced liver cancer in rats.

Authors:  A Aitio; M L Aitio; A M Camus; E Cardis; H Bartsch
Journal:  Jpn J Cancer Res       Date:  1991-02
  6 in total

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