Glucuronide formation in the metabolism of N-substituted aryl compounds.

N-Glucuronide conjugates of N-arylhydroxylamines and O-glucuronides of N-acetyl-N-arylhydroxylamines may play significant roles in the extrahepatic carcinogenicity of arylamines by serving as stable transport forms of metabolically activated precursors. In extrahepatic target organs, these glucuronides can undergo pH-dependent hydrolytic reactions to liberate an activated metabolite or one capable of being further activated.