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Literature DB >> 7340465

Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole (6-SAI).

Abstract

Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was inhibited after a single dosage or seven administration of 6-SAI to old rats. These effects were independent of the development of arthritis. Changes in cytochrome P-450 concentration after 6-SAI treatment were insignificant and thus not responsible for the decrease in drug metabolism. In vitro 6-SAI inhibited ethylmorphine N-demethylation; the inhibition was of a mixed type. 6-SAI bound to cytochrome P-450 and induced a type II spectrum. The magnitude of hexobarbital-induced type I spectral changes was diminished by 6-SAI. It is concluded that 6-SAI inhibits cytochrome P-450-dependent drug metabolism by binding to cytochrome P-450.

Entities: Chemical Disease Species

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Year: 1981 PMID： 7340465 DOI： 10.1007/bf01978798

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

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References

17 in total

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Drug metabolism in rats with arthritis induced by 6-sulfanilamidoindazole (6-SAI).

1. THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE.

2. [Stimulation of several microsomal drug oxidations by phenobarbital, methylcholanthrene and chlorophenothane, single and in combinations].

3. Reconstituted liver microsomal enzyme system that hydroxylates drugs, other foreign compounds, and endogenous substrates. II. Role of the cytochrome P-450 and P-448 fractions in drug and steroid hydroxylations.

4. Spectral studies of drug interaction with hepatic microsomal cytochrome.

5. The nature of the reverse type I (modified type II) spectral change in liver microsomes.

6. 6-sulfanilamidoindazole induced arthritis and periarthritis in rats. A new model of experimental inflammation.

7. The role of mycoplasma in rat arthritis induced by 6-sulfanilamidoindazole.

Review 8. Impaired drug metabolism in rats with adjuvant-induced arthritis: a brief review.

9. Impaired metabolic handling of drugs in rats with arthritis induced by 6-sulfonanilamidoindazole.

10. Induction of periarthritis by oral administration of 6-sulfanilamidoindazole and its treatment in rats.