Literature DB >> 733940

Amelioration of cis-platinum nephrotoxicity by orgotein (superoxide dismutase).

J E McGinness, P H Proctor, H B Demopoulos, J A Hokanson, D S Kirkpatrick.   

Abstract

In rats, daily administration of subcutaneous dose of 2.5 mg/kg of orgotein, the pharmaceutical preparation of Zn-Cu superoxide dismutase, lowers the nephrotoxicity induced by a 5.0 mg/kg dose of the antitumor agent cis-platinum (cis-diaminedichloroplatinum II). The toxicity of cis-platinum was studied by comparative measurements of blood urea nitrogen and changes in body weight, and by comparative renal histology. In addition to their direct clinical applicability, these results support a role for pathologic levels of oxygen radicals in the etiology of the nephrotoxicity of cis-platinum.

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Year:  1978        PMID： 733940

Source DB:  PubMed          Journal:  Physiol Chem Phys        ISSN： 0031-9325


  13 in total

1.  Protection against cisplatin-induced lipid peroxidation and kidney damage by procaine in rats.

Authors:  L F Zhong; J G Zhang; M Zhang; S L Ma; Y X Xia
Journal:  Arch Toxicol       Date:  1990       Impact factor: 5.153

2.  Sodium thiosulfate fails to increase the therapeutic index of intravenously administered cis-diamminedichloroplatinum (II) in mice bearing murine and human tumors.

Authors:  S Aamdal; O Fodstad; A Pihl
Journal:  Cancer Chemother Pharmacol       Date:  1988       Impact factor: 3.333

3.  Protection effects of procaine on oxidative stress and toxicities of renal cortical slices from rats caused by cisplatin in vitro.

Authors:  J G Zhang; L F Zhong; M Zhang; Y X Xia
Journal:  Arch Toxicol       Date:  1992       Impact factor: 5.153

4.  Protection by ebselen against cisplatin-induced nephrotoxicity: antioxidant system.

Authors:  K Husain; C Morris; C Whitworth; G L Trammell; L P Rybak; S M Somani
Journal:  Mol Cell Biochem       Date:  1998-01       Impact factor: 3.396

5.  The mode of cisplatin-induced cell death in CYP2E1-overexpressing HepG2 cells: modulation by ERK, ROS, glutathione, and thioredoxin.

Authors:  Yongke Lu; Arthur Cederbaum
Journal:  Free Radic Biol Med       Date:  2007-07-06       Impact factor: 7.376

6.  Factors affecting human autopsy kidney-cortex and kidney-medulla platinum concentrations after cisplatin administration.

Authors:  D J Stewart; C Dulberg; J M Molepo; N Z Mikhael; V A Montpetit; M D Redmond; R Goel
Journal:  Cancer Chemother Pharmacol       Date:  1994       Impact factor: 3.333

7.  Protective effect of piperacillin against the nephrotoxicity of cisplatin in rats.

Authors:  T Hayashi; Y Watanabe; K Kumano; R Kitayama; T Muratani; T Yasuda; I Saikawa; J Katahira; T Kumada; K Shimizu
Journal:  Antimicrob Agents Chemother       Date:  1989-04       Impact factor: 5.191

Review 8.  Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention.

Authors:  Jochen Schacht; Andra E Talaska; Leonard P Rybak
Journal:  Anat Rec (Hoboken)       Date:  2012-10-08       Impact factor: 2.064

9.  Redox control of resistance to cis-diamminedichloroplatinum (II) (CDDP): protective effect of human thioredoxin against CDDP-induced cytotoxicity.

Authors:  T Sasada; S Iwata; N Sato; Y Kitaoka; K Hirota; K Nakamura; A Nishiyama; Y Taniguchi; A Takabayashi; J Yodoi
Journal:  J Clin Invest       Date:  1996-05-15       Impact factor: 14.808

Review 10.  Drug-induced ototoxicity. Pathogenesis and prevention.

Authors:  M Y Huang; J Schacht
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Nov-Dec
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