Evaluation of the antiasthmatic potential of oxarbazole in guinea pigs.

Oxarbazole, 9-benzoyl-2,3,4,9,-tetrahydro-6-methoxy-1H-carbazole-3-carboxylic acid, inhibited bronchoconstriction induced by a crude SRS-A preparation or by bradykinin in dose-related manner in anesthetized guinea pigs. Oxarbazole was ineffective against bronchoconstriction induced by histamine, carbachol, serotonin, or PGF2alpha. Inhibition of bonchoconstriction induced by the crude SRS-A preparation by oxarbazole was unimpeded by the presence of beta-adrenergic- or cholinergic-blocking agents, but it could be overcome by increased doses of the SRS-A preparation.