Literature DB >> 7338532

Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats.

H Brune, R P Deutsch-Wenzel, M Habs, S Ivankovic, D Schmähl.   

Abstract

In a lifetime experiment benzo(a)pyrene (B(a)P) was administered to Sprague-Dawley rats either as an admixture to the diet or by gavage in an aqueous 1.5% caffeine solution. Dissolved benzo(a)pyrene induced more tumors of the forestomach than undissolved benzo(a)pyrene. The 1.5% caffeine solution (annual dose 27 g/kg) did not exert any carcinogenic activity under the conditions of this bioassay.

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Year:  1981        PMID： 7338532     DOI： 10.1007/bf00410666

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  7 in total

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Authors:  K SETALA
Journal:  Nature       Date:  1954-11-06       Impact factor: 49.962

2.  Gastric absorption of 3,4-benzpyrene. II. The significance of the solvent for the penetration of 3,4-benzpyrene into the stomach wall.

Authors:  P EKWALL; P ERMALA; K SETALA
Journal:  Cancer Res       Date:  1951-10       Impact factor: 12.701

3.  [Study of the carcinogenic action of orally administered 9, 10-dimethylbenzanthracene and 3,4-benzopyrene].

Authors:  I Chouroulinkov; A Gentil; M Guérin
Journal:  Bull Cancer       Date:  1967 Jan-Mar       Impact factor: 1.276

4.  [Mucosal tumors of the phrenic ampulla of mice following benzpyrene feeding].

Authors:  W Griem; K Engelhardt
Journal:  Z Krebsforsch       Date:  1968

5.  [Carcinogens in water and soil. XXII. Experiment with 3,4-benzopyrene and potassium chromate in mice drink].

Authors:  J Borneff; K Engelhardt; W Griem; H Kunte; J Reichert
Journal:  Arch Hyg Bakteriol       Date:  1968-01

6.  Gastric tumors in mice fed benzo(a)pyrene: a quantitative study.

Authors:  J Neal; R H Rigdon
Journal:  Tex Rep Biol Med       Date:  1967

7.  Editorial: Guidelines on the analysis of tumour rates and death rates in experimental animals.

Authors:  R Peto
Journal:  Br J Cancer       Date:  1974-02       Impact factor: 7.640
  7 in total
  8 in total

Review 1.  Polycyclic aromatic hydrocarbons and digestive tract cancers: a perspective.

Authors:  Deacqunita L Diggs; Ashley C Huderson; Kelly L Harris; Jeremy N Myers; Leah D Banks; Perumalla V Rekhadevi; Mohammad S Niaz; Aramandla Ramesh
Journal:  J Environ Sci Health C Environ Carcinog Ecotoxicol Rev       Date:  2011-10       Impact factor: 3.781

Review 2.  Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke.

Authors:  S S Hecht
Journal:  Tob Control       Date:  2004-03       Impact factor: 7.552

3.  To BaP or not to BaP? That is the question.

Authors:  L S Goldstein
Journal:  Environ Health Perspect       Date:  2001-08       Impact factor: 9.031

4.  Application of benzo(a)pyrene and coal tar tumor dose-response data to a modified benchmark dose method of guideline development.

Authors:  D James Fitzgerald; Neville I Robinson; Beverly A Pester
Journal:  Environ Health Perspect       Date:  2004-10       Impact factor: 9.031

Review 5.  Chronological supplement to the Carcinogenic Potency Database: standardized results of animal bioassays published through December 1982.

Authors:  L S Gold; M de Veciana; G M Backman; R Magaw; P Lopipero; M Smith; M Blumenthal; R Levinson; L Bernstein; B N Ames
Journal:  Environ Health Perspect       Date:  1986-08       Impact factor: 9.031

6.  Quantitative and temporal relationships between DNA adduct formation in target and surrogate tissues: implications for biomonitoring.

Authors:  S Nesnow; J Ross; G Nelson; K Holden; G Erexson; A Kligerman; R C Gupta
Journal:  Environ Health Perspect       Date:  1993-10       Impact factor: 9.031

Review 7.  Establishing generic remediation goals for the polycyclic aromatic hydrocarbons: critical issues.

Authors:  P K LaGoy; T C Quirk
Journal:  Environ Health Perspect       Date:  1994-04       Impact factor: 9.031

8.  PM-Bound Polycyclic Aromatic Hydrocarbons and Nitro-Polycyclic Aromatic Hydrocarbons in the Ambient Air of Vladivostok: Seasonal Variation, Sources, Health Risk Assessment and Long-Term Variability.

Authors:  Yan Wang; Hao Zhang; Xuan Zhang; Pengchu Bai; Andrey Neroda; Vassily F Mishukov; Lulu Zhang; Kazuichi Hayakawa; Seiya Nagao; Ning Tang
Journal:  Int J Environ Res Public Health       Date:  2022-03-01       Impact factor: 3.390
  8 in total

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