Literature DB >> 7337981

Alteration of the circulating life and antigenic properties of bovine adenosine deaminase in mice by attachment of polyethylene glycol.

S Davis, A Abuchowski, Y K Park, F F Davis.   

Abstract

Polyethylene glycol was attached covalently to adenosine deaminase (ADA) using cyanuric chloride as the coupling agent. The modified adenosine deaminase (PEG-ADA) appears to lose its immunogenicity in mice following multiple intravenous injections. PEG-ADA does not react with antibodies raised against native ADA. The circulating half-life (T1/2) of PEG-ADA was increased to 28 hr. The lack of detectable antibody formation and long circulating life may make PEG-ADA suitable for treating human ADA deficiency.

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Year:  1981        PMID： 7337981      PMCID： PMC1536305     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  5 in total

1.  Determination of free amino groups in proteins by trinitrobenzenesulfonic acid.

Authors:  A F Habeeb
Journal:  Anal Biochem       Date:  1966-03       Impact factor: 3.365

2.  Combined immunodeficiency disease associated with adenosine deaminase deficiency. Report on a workshop held in Albany, New York, October 1, 1973.

Authors:  H J Meuwissen; B Pollara; R J Pickering
Journal:  J Pediatr       Date:  1975-02       Impact factor: 4.406

3.  Enzyme replacement therapy for adenosine deaminase deficiency and severe combined immunodeficiency.

Authors:  S H Polmar; R C Stern; A L Schwartz; E M Wetzler; P A Chase; R Hirschhorn
Journal:  N Engl J Med       Date:  1976-12-09       Impact factor: 91.245

4.  Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

Authors:  A Abuchowski; T van Es; N C Palczuk; F F Davis
Journal:  J Biol Chem       Date:  1977-06-10       Impact factor: 5.157

5.  Reconstitution of B and T lymphocyte function in severe combined immunodeficiency disease after transplantation with thymic epithelium.

Authors:  R Hong; M Santosham; H Schulte-Wissermann; S Horowitz; S H Hsu; J A Winkelstein
Journal:  Lancet       Date:  1976-12-11       Impact factor: 79.321
  5 in total
  21 in total

1.  Conjugates bearing multiple formyl-methionyl peptides display enhanced binding to but not activation of phagocytic cells.

Authors:  Shahriar Pooyan; Bo Qiu; Marion M Chan; Dunne Fong; Patrick J Sinko; Michael J Leibowitz; Stanley Stein
Journal:  Bioconjug Chem       Date:  2002 Mar-Apr       Impact factor: 4.774

2.  Comparison of elapegademase and pegademase in ADA-deficient patients and mice.

Authors:  L Murguia-Favela; W Min; R Loves; M Leon-Ponte; E Grunebaum
Journal:  Clin Exp Immunol       Date:  2020-02-09       Impact factor: 4.330

3.  Enhanced brain distribution of modified aspartoacylase.

Authors:  Nitesh K Poddar; Stephen Zano; Reka Natarajan; Bryan Yamamoto; Ronald E Viola
Journal:  Mol Genet Metab       Date:  2014-07-12       Impact factor: 4.797

4.  Comparison of long-acting bevacizumab formulations in the treatment of choroidal neovascularization in a rat model.

Authors:  Carolyn K Pan; Chandrasekar Durairaj; Uday B Kompella; Ogechi Agwu; Scott C N Oliver; Hugo Quiroz-Mercado; Naresh Mandava; Jeffrey L Olson
Journal:  J Ocul Pharmacol Ther       Date:  2011-05-16       Impact factor: 2.671

Review 5.  Erythrocyte-mediated delivery of recombinant enzymes.

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Journal:  J Inherit Metab Dis       Date:  2016-03-30       Impact factor: 4.982

Review 6.  Enzymes as Immunotherapeutics.

Authors:  Shaheen A Farhadi; Evelyn Bracho-Sanchez; Sabrina L Freeman; Benjamin G Keselowsky; Gregory A Hudalla
Journal:  Bioconjug Chem       Date:  2018-01-31       Impact factor: 4.774

7.  Effect of chemical modification of recombinant human acetylcholinesterase by polyethylene glycol on its circulatory longevity.

Authors:  O Cohen; C Kronman; T Chitlaru; A Ordentlich; B Velan; A Shafferman
Journal:  Biochem J       Date:  2001-08-01       Impact factor: 3.857

8.  Fingerprinting proteins coupled with polymers by mass spectrometry: Investigation of polyethylene glycol-conjugated superoxide dismutase.

Authors:  S K Chowdhury; M Doleman; D Johnston
Journal:  J Am Soc Mass Spectrom       Date:  1995-06       Impact factor: 3.109

9.  Characterization and stability of N-terminally PEGylated rhG-CSF.

Authors:  O B Kinstler; D N Brems; S L Lauren; A G Paige; J B Hamburger; M J Treuheit
Journal:  Pharm Res       Date:  1996-07       Impact factor: 4.200

10.  Pegademase bovine (PEG-ADA) for the treatment of infants and children with severe combined immunodeficiency (SCID).

Authors:  Claire Booth; H Bobby Gaspar
Journal:  Biologics       Date:  2009-07-13
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