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Literature DB >> 7337928

Antitumor activity of acylated oridonin.

E Fujita, Y Nagao, T Kohno, M Matsuda, M Ozaki.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 1981 PMID： 7337928 DOI： 10.1248/cpb.29.3208

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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7 in total

1. Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

Authors: Chunyong Ding; Yusong Zhang; Haijun Chen; Zhengduo Yang; Christopher Wild; Na Ye; Corbin D Ester; Ailian Xiong; Mark A White; Qiang Shen; Jia Zhou
Journal: J Med Chem Date: 2013-10-31 Impact factor: 7.446

2. Effect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazole.

Authors: C Murayama; Y Nagao; S Sano; M Ochiai; K Fuji; E Fujita; T Mori
Journal: Experientia Date: 1987-12-01

3. Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position.

Authors: Chunyong Ding; Yusong Zhang; Haijun Chen; Christopher Wild; Tianzhi Wang; Mark A White; Qiang Shen; Jia Zhou
Journal: Org Lett Date: 2013-07-08 Impact factor: 6.005

4. Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.

Authors: Chunyong Ding; Yusong Zhang; Haijun Chen; Zhengduo Yang; Christopher Wild; Lili Chu; Huiling Liu; Qiang Shen; Jia Zhou
Journal: J Med Chem Date: 2013-06-19 Impact factor: 7.446

Antitumor activity of acylated oridonin.

1. Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis.

2. Effect of oridonin, a Rabdosia diterpenoid, on radiosensitization with misonidazole.

3. Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position.

4. Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility.

5. Structural modification of oridonin via DAST induced rearrangement.

6. Anti-tumor activity of oridonin on SNU-5 subcutaneous xenograft model via regulation of c-Met pathway.

Review 7. Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound.