Literature DB >> 7337707

The inactivation of aldehyde dehydrogenase by disulfiram in the presence of glutathione.

T M Kitson.   

Abstract

It is shown that in vitro glutathione provides little protection of cytoplasmic aldehyde dehydrogenase against the inactivatory action of disulfiram. This observation provides support for the current explanation of how disulfiram acts in vivo. The results show that the disulfiram-sensitive thiol groups of aldehyde dehydrogenase have an unusually high reactivity; possible mechanisms by which this might arise are discussed.

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Year:  1981        PMID： 7337707      PMCID： PMC1163359          DOI： 10.1042/bj1990255

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  18 in total

1.  Some properties of aldehyde dehydrogenase from sheep liver mitochondria.

Authors:  G J Hart; F M Dickinson
Journal:  Biochem J       Date:  1977-05-01       Impact factor: 3.857

2.  The effect of disulfiram on the aldehyde dehydrogenases of sheep liver.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1975-11       Impact factor: 3.857

3.  Kinetics of sheep-liver cytoplasmic aldehyde dehydrogenase.

Authors:  A K MacGibbon; L F Blackwell; P D Buckley
Journal:  Eur J Biochem       Date:  1977-07-01

Review 4.  The disulfiram--ethanol reaction: a review.

Authors:  T M Kitson
Journal:  J Stud Alcohol       Date:  1977-01

5.  Intracellular localisation and properties of aldehyde dehydrogenases from sheep liver.

Authors:  K E Crow; T M Kitson; A K MacGibbon; R D Batt
Journal:  Biochim Biophys Acta       Date:  1974-05-20

6.  Mechanism of the inhibition of aldehyde dehydrogenase in vivo by disulfiram and diethyldithiocarbamate.

Authors:  R A Deitrich; V G Erwin
Journal:  Mol Pharmacol       Date:  1971-05       Impact factor: 4.436

Review 7.  The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis.

Authors:  E Boyland; L F Chasseaud
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1969

8.  Two aldehyde dehydrogenases from human liver. Isolation via affinity chromatography and characterization of the isozymes.

Authors:  N J Greenfield; R Pietruszko
Journal:  Biochim Biophys Acta       Date:  1977-07-08

9.  The rapid reduction of disulfiram in blood and plasma.

Authors:  J Cobby; M Mayersohn; S Selliah
Journal:  J Pharmacol Exp Ther       Date:  1977-09       Impact factor: 4.030

10.  Enzymatic oxidation of diethyldithiocarbamate by xanthine oxidase and its colorimetric assay.

Authors:  R Fried
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691
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  7 in total

1.  Modulation of the reactivity of the essential cysteine residue of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa.

Authors:  Lilian González-Segura; Roberto Velasco-García; Rosario A Muñoz-Clares
Journal:  Biochem J       Date:  2002-02-01       Impact factor: 3.857

2.  Mechanism of inactivation of sheep liver cytoplasmic aldehyde dehydrogenase by disulfiram.

Authors:  T M Kitson
Journal:  Biochem J       Date:  1983-08-01       Impact factor: 3.857

3.  Aldehyde dehydrogenase. An enzyme with two distinct catalytic activities at a single type of active site.

Authors:  R J Duncan
Journal:  Biochem J       Date:  1985-08-15       Impact factor: 3.857

Review 4.  Recent Advances in Antabuse (Disulfiram): The Importance of its Metal-binding Ability to its Anticancer Activity.

Authors:  Maricela Viola-Rhenals; Kush R Patel; Laura Jaimes-Santamaria; Guojun Wu; Jinbao Liu; Q Ping Dou
Journal:  Curr Med Chem       Date:  2018-02-12       Impact factor: 4.530

5.  Inhibition of erythrocyte aldehyde dehydrogenase activity and elimination kinetics of diethyldithiocarbamic acid methyl ester and its monothio analogue after administration of single and repeated doses of disulfiram to man.

Authors:  B Johansson; Z Stankiewicz
Journal:  Eur J Clin Pharmacol       Date:  1989       Impact factor: 2.953

6.  Effect of pyrophosphate ions and alkaline pH on the kinetics of propionaldehyde oxidation by sheep liver cytosolic aldehyde dehydrogenase.

Authors:  J P Hill; P D Buckley; L F Blackwell; R L Motion
Journal:  Biochem J       Date:  1991-02-01       Impact factor: 3.857

7.  Inactivation of Aldehyde Dehydrogenase by Disulfiram in the Presence and Absence of Lipoic Acid or Dihydrolipoic Acid: An in Vitro Study.

Authors:  Anna Bilska-Wilkosz; Magdalena Górny; Małgorzata Iciek
Journal:  Biomolecules       Date:  2019-08-16
  7 in total

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