Literature DB >> 7337074

The topically irritant substance: essentials - bio-tests - predictions.

K Bucher, K E Bucher, D Walz.   

Abstract

The paper describes a method for judging the irritative potentialities of substances; proposes a scoring system with which the 'ordinary' risks of many of the abundant marketed products for washing, cleaning etc. may be predicted without biological testing; discusses pharmacodynamic and pharmacokinetic aspects of topical irritancy and points to the problems of extrapolating from animal experiments to man.

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Year:  1981        PMID： 7337074     DOI： 10.1007/bf02004715

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  4 in total

1.  Relative eye-injury potential of heavy-duty phosphate and non-phosphate laundry detergents.

Authors:  L G Scharpf; I D Hill; R E Kelly
Journal:  Food Cosmet Toxicol       Date:  1972-12

2.  Evaluation of ocular irritation in the rabbit: objective versus subjective assessment.

Authors:  P Conquet; G Durand; J Laillier; B Plazonnet
Journal:  Toxicol Appl Pharmacol       Date:  1977-01       Impact factor: 4.219

3.  Eye irritation from topically applied drugs and cosmetics: preclinical studies.

Authors:  F N Marzulli; M E Simon
Journal:  Am J Optom Arch Am Acad Optom       Date:  1971-01

4.  Irritant actions of unphysiological pH values. A controlled procedure to test for topical irritancy.

Authors:  K Bucher; K E Bucher; D Walz
Journal:  Agents Actions       Date:  1979-04
  4 in total
  2 in total

1.  The quantitative assessment of topical irritancy and its application to unphysiological pH-values.

Authors:  D Walz; K E Bucher
Journal:  Agents Actions       Date:  1982-10

2.  The relationship of pKa and acute skin irritation in man.

Authors:  B Berner; D R Wilson; R H Guy; G C Mazzenga; F H Clarke; H I Maibach
Journal:  Pharm Res       Date:  1988-10       Impact factor: 4.200
  2 in total

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