Literature DB >> 7337069

Alpha-methylhistamine methylation by histamine methyltransferase.

L B Hough, J K Khandelwal, T W Mittag.   

Abstract

Enzymatic methylation of histamine and analogues by histamine methyltransferase (HMT) was studied. Incubation of histamine or alpha-methylhistamine with HMT and S-adenosylmethionine was shown by GC-MS to yield tele-methyl and alpha-methyl-tele-methyl-histamine, respectively. Kinetic analysis of the reactions indicated that both substrates exhibited equivalent Vmax values, but that histamine's Km was ten-fold lower than that of alpha-methylhistamine. These results indicate that alpha-methylhistamine can be methylated as effectively as histamine, and may be a useful tool in further studies of HMT.

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Year:  1981        PMID： 7337069     DOI： 10.1007/bf02004701

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  14 in total

1.  Increased sensitivity of the enzymatic isotopic assay of histamine: measurement of histamine in plasma and serum.

Authors:  R E Shaff; M A Beaven
Journal:  Anal Biochem       Date:  1979-04-15       Impact factor: 3.365

2.  Catabolism of physiological quantities of histamine in vivo.

Authors:  R W SCHAYER
Journal:  Physiol Rev       Date:  1959-01       Impact factor: 37.312

3.  The distribution and properties of a histamine-methylating enzyme.

Authors:  D D BROWN; R TOMCHICK; J AXELROD
Journal:  J Biol Chem       Date:  1959-11       Impact factor: 5.157

4.  Ring N methylation; a major route of histamine metabolism.

Authors:  R W SCHAYER; S A KARJALA
Journal:  J Biol Chem       Date:  1956-07       Impact factor: 5.157

5.  Definition and antagonism of histamine H 2 -receptors.

Authors:  J W Black; W A Duncan; C J Durant; C R Ganellin; E M Parsons
Journal:  Nature       Date:  1972-04-21       Impact factor: 49.962

6.  Isotopic microassay of histamine, histidine, histidine decarboxylase and histamine methyltransferase in brain tissue.

Authors:  K M Taylor; S H Snyder
Journal:  J Neurochem       Date:  1972-05       Impact factor: 5.372

7.  Evidence for a less high acceptor substrate specificity of gastric histamine methyltransferase: methylation of imidazole compounds.

Authors:  H Barth; M Crombach; W Schunack; W Lorenz
Journal:  Biochem Pharmacol       Date:  1980-05-15       Impact factor: 5.858

8.  Gas chromatography--mass spectrometric characteristics and assay of tele-methylhistamine.

Authors:  L B Hough; P L Stetson; E F Domino
Journal:  Anal Biochem       Date:  1979-07-01       Impact factor: 3.365

9.  Brain histamine N-methyltransferase purification, mechanism of action, and inhibition by drugs.

Authors:  A Thithapandha; V H Cohn
Journal:  Biochem Pharmacol       Date:  1978-02-01       Impact factor: 5.858

10.  An improved GCMS method to measure tele-methylhistamine.

Authors:  L B Hough; J K Khandelwal; A M Morrishow; J P Green
Journal:  J Pharmacol Methods       Date:  1981-03
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  2 in total

1.  Reliability and practicability of the fluorometric-fluoroenzymatic histamine determination in pathogenetic studies on peptic ulcer: detection limits and problems with specificity.

Authors:  W Lorenz; K Thon; E Neugebauer; H Stöltzing; C Ohmann; D Weber; A Schmal; E Hinterlang; H Barth; J Kusche
Journal:  Agents Actions       Date:  1987-06

2.  Gastric histamine methyltransferase: different methylation rates for enantiomers of side-chain methylated histamine analogues using a highly purified enzyme preparation.

Authors:  H Barth; W Schunack; M Crombach; W Lorenz
Journal:  Agents Actions       Date:  1984-04
  2 in total

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