Literature DB >> 7336464

17 alpha-alkynyl-11 beta, 17-dihydroxyandrostane derivatives : a new class of potent glucocorticoids.

G Teutsch, G Costerousse, R Deraedt, J Benzoni, M Fortin, D Philibert.   

Abstract

Replacement of the characteristic dihydroxyacetone side chain of corticoids by a 17 alpha-alkynyl-17 beta-hydroxy moiety was investigated. It was found that, in particular, the 17 alpha-propynyl substitution is favorable for high local anti-inflammatory activity with reduced systemic effects. Moreover, these compounds were found to be devoid of any affinity for the aldosterone receptor, and may thus be considered as pure glucocorticoids.

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Year:  1981        PMID： 7336464     DOI： 10.1016/0039-128x(81)90084-2

Source DB:  PubMed          Journal:  Steroids        ISSN： 0039-128X            Impact factor:   2.668


  13 in total

1.  Glucocorticoids in the prefrontal cortex enhance memory consolidation and impair working memory by a common neural mechanism.

Authors:  Areg Barsegyan; Scott M Mackenzie; Brian D Kurose; James L McGaugh; Benno Roozendaal
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-01       Impact factor: 11.205

2.  Persistent disruption of a traumatic memory by postretrieval inactivation of glucocorticoid receptors in the amygdala.

Authors:  Sophie Tronel; Cristina M Alberini
Journal:  Biol Psychiatry       Date:  2007-01-03       Impact factor: 13.382

3.  Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors.

Authors:  S G Turnamian; H J Binder
Journal:  J Clin Invest       Date:  1989-12       Impact factor: 14.808

4.  Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation.

Authors:  B Roozendaal; D J de Quervain; B Ferry; B Setlow; J L McGaugh
Journal:  J Neurosci       Date:  2001-04-01       Impact factor: 6.167

5.  The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala.

Authors:  Benno Roozendaal; Qyana K Griffith; Jason Buranday; Dominique J-F De Quervain; James L McGaugh
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-21       Impact factor: 11.205

6.  Glucocorticoid effects on memory consolidation depend on functional interactions between the medial prefrontal cortex and basolateral amygdala.

Authors:  Benno Roozendaal; Jayme R McReynolds; Eddy A Van der Zee; Sangkwan Lee; James L McGaugh; Christa K McIntyre
Journal:  J Neurosci       Date:  2009-11-11       Impact factor: 6.167

7.  Methylprednisolone protects oligodendrocytes but not neurons after spinal cord injury.

Authors:  Jin-Moo Lee; Ping Yan; Qingli Xiao; Shawei Chen; Kuang-Yung Lee; Chung Y Hsu; Jan Xu
Journal:  J Neurosci       Date:  2008-03-19       Impact factor: 6.167

8.  Characterization of a monoclonal antibody that probes the functional domains of the glucocorticoid receptor.

Authors:  N M Robertson; W F Kusmik; B F Grove; A Miller-Diener; M L Webb; G Litwack
Journal:  Biochem J       Date:  1987-08-15       Impact factor: 3.857

9.  Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activation.

Authors:  Benno Roozendaal; Gustav Schelling; James L McGaugh
Journal:  J Neurosci       Date:  2008-06-25       Impact factor: 6.167

10.  Regulation of cation transport by low doses of glucocorticoids in in vivo adrenalectomized rat colon.

Authors:  C P Bastl
Journal:  J Clin Invest       Date:  1987-08       Impact factor: 14.808
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