Serum immunoglobulins in fixed drug eruption.

The serum globulins IgG, IgA and IgM were studied in the serum of 47 patients with fixed drug eruption due to identified drugs. The diagnosis was established by using as a test the readministration of the responsible drug and the consequent appearance of the eruption. IgM was found in normal amounts in the acute phase and after the remission of the eruption, whereas IgG and IgA were found increased during the acute phase of the eruption though after the remission, levels returned to normal.