Literature DB >> 7329216

Lethal effect of cis- but not trans-22-dehydrocholesterol on mouse fibroblast cells.

H W Kircher, F U Rosenstein, A A Kandutsch.   

Abstract

cis- and trans-22-dehydrocholesterol were incorporated into the culture medium for mouse fibroblasts cells. Although neither isomer had an effect on sterol biosynthesis, the cis isomer inhibited cell growth and viability and increased Rb+ efflux from the cells. The trans isomer had no effect on growth and could replace exogenous cholesterol for growth of cells for which sterol biosynthesis was blocked by 25-hydroxycholesterol.

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Year:  1981        PMID： 7329216     DOI： 10.1007/bf02535004

Source DB:  PubMed          Journal:  Lipids        ISSN： 0024-4201            Impact factor:   1.880


  11 in total

1.  The steric requirements for sterol inhibition of tetrahymanol biosynthesis.

Authors:  R L Conner; J R Landrey
Journal:  Lipids       Date:  1978-10       Impact factor: 1.880

2.  Inactive 3-hydroxy-3-methylglutaryl-coenzyme A reductase in broken cell preparations of various mammalian tissues and cell cultures.

Authors:  S E Saucier; A A Kandutsch
Journal:  Biochim Biophys Acta       Date:  1979-03-29

3.  Modification of the Lowry procedure for the analysis of proteolipid protein.

Authors:  M B Lees; S Paxman
Journal:  Anal Biochem       Date:  1972-05       Impact factor: 3.365

4.  Inhibition of sterol biosynthesis in L cells and mouse liver cells by 15-oxygenated sterols.

Authors:  G J Schroepfer; E J Parish; H W Chen; A A Kandutsch
Journal:  J Biol Chem       Date:  1977-12-25       Impact factor: 5.157

5.  Biological activity of some oxygenated sterols.

Authors:  A A Kandutsch; H W Chen; H J Heiniger
Journal:  Science       Date:  1978-08-11       Impact factor: 47.728

6.  Sterol to phospholipid molar ratios of L cells with qualitative and quantitative variations of cellular sterol.

Authors:  L Sokoloff; G H Rothblat
Journal:  Proc Soc Exp Biol Med       Date:  1974-09

7.  The synthesis and the mass and nuclear magnetic resonance spectra of side chain isomers of cholesta-5, 22-dien-3-beta-ol and cholesta-5,22, 24-trien-3-beta-ol.

Authors:  R F Hutchins; M J Thompson; J A Svoboda
Journal:  Steroids       Date:  1970-01       Impact factor: 2.668

8.  Models for lipid organization in cholesterol-phospholipid bilayers including cholesterol dimer formation.

Authors:  R B Martin; P L Yeagle
Journal:  Lipids       Date:  1978-09       Impact factor: 1.880

9.  Titration of sterol double bonds with dibromopyridine sulfate.

Authors:  F U Rosenstein; R Caruso; H W Kircher
Journal:  Lipids       Date:  1977-03       Impact factor: 1.880

10.  Inhibition of sterol synthesis in cultured mouse cells by 7alpha-hydroxycholesterol, 7beta-hydroxycholesterol, and 7-ketocholesterol.

Authors:  A A Kandutsch; H W Chen
Journal:  J Biol Chem       Date:  1973-12-25       Impact factor: 5.157
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  1 in total

1.  Response of Drosophila to cis- and trans-22-dehydrocholesterol: I. A survey.

Authors:  H W Kircher; R L Phariss; F U Rosenstein; D Baldwin; J C Fogleman
Journal:  Lipids       Date:  1982-03       Impact factor: 1.880
  1 in total

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