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Literature DB >> 7329213

Enzymatic formation of cholesteryl ester from cholesterol by gallbladder mucosa.

Abstract

The formation of cholesteryl ester from cholesterol and acyl CoA catalyzed by the enzyme acyl CoA:cholesterol acyltransferase (EC 2.3.1.26) was studied in guinea pig gallbladder mucosa homogenate and the subcellular fractions. The enzymatic activity was enriched in the microsomal fraction. Highest activity was observed with palmitoyl, stearoyl or oleoyl CoA as substrate. Lowest activity was observed with linoleoyl CoA. These data elucidate one mechanism for the formation of cholesteryl ester from cholesterol by the gallbladder wall.

Entities: Chemical Species

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Year: 1981 PMID： 7329213 DOI： 10.1007/bf02535000

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

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References

25 in total

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Authors: S Balasubramaniam; S Venkatesan; K A Mitropoulos; T J Peters
Journal: Biochem J Date: 1978-09-15 Impact factor: 3.857

Enzymatic formation of cholesteryl ester from cholesterol by gallbladder mucosa.

1. THE FORMATION OF CHOLESTEROL ESTERS WITH RAT LIVER ENZYMES.

2. Lipid metabolism by The gall-bladder. II. The in vitro conversion of lysophosphatidylcholine to phosphatidylcholine.

3. Cholesteryl ester synthesis in normal and atherosclerotic aortas of rabbits and rhesus monkeys.

4. Absorption of oleic acid by the guinea pig gallbladder.

5. The submicrosomal localization of acyl-coenzyme A-cholesterol acyltransferase and its substrate, and of cholesteryl esters in rat liver.

6. Studies on the importance of lecithin for cholesterol solubilization in bile.

7. Removal of fatty acids from serum albumin by charcoal treatment.

8. Esterification of cholesterol in human small intestine: the importance of acyl-CoA:cholesterol acyltransferase.

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10. Lipid metabolism by the gall-bladder. I. The in situ uptake and metabolism of lysophosphatidylcholine.