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Literature DB >> 732896

Crude substance P from brain contains a cholecystokinin-like peptide.

G Zetler, D Cannon, D Powell, P Skrabanek, J J Vanderhaeghen.

Abstract

The subfractions Fa, Fb, and Fc of crude substance P (SP) preparations made from human and bovine brains were analysed for SP and the COOH-terminal octapeptide of cholecystokinin (CCK-8). The methods were specific radioimmunoassays (RIAs) for SP and CCK-8, and bioassays on isolated organs of the guinea pig: the ileum, the gallbladder and the field-stimulated vas deferens. 1. In bioassays of synthetic peptides the vas deferens reacted specifically to SP and the gallbladder to CCK-8. 2. RIAs and bioassays revealed unequivocally that most of SP-like activity was present in Fb, while Fc contained mainly CCK-8-like activity. Varying results were obtained with Fa. 3. The pharmacologically active principle of Fc is CCK-8 or a closely related peptide. Earlier results concerning the pharmacological and neurochemical properties of Fc must be ascribed to this peptide.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1978 PMID： 732896 DOI： 10.1007/bf00508292

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

11 in total

1. New peptide in the vertebrate CNS reacting with antigastrin antibodies.

Authors: J J Vanderhaeghen; J C Signeau; W Gepts
Journal: Nature Date: 1975-10-16 Impact factor: 49.962

2. [Substance P, a polypeptide from the intestine and the brain, with depressive, hyperalgesic and morphine antagonist effects on CNS].

Authors: G ZETLER
Journal: Naunyn Schmiedebergs Arch Exp Pathol Pharmakol Date: 1956

3. High-sensitivity radioimmunoassay for substance P.

Authors: R O'Connell; P Skrabanek; D Cannon; D Powell
Journal: Ir J Med Sci Date: 1976-12 Impact factor: 1.568

4. Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.

Authors: P Robberecht; M Deschodt-Lanckman; J J Vanderhaeghen
Journal: Proc Natl Acad Sci U S A Date: 1978-01 Impact factor: 11.205

Crude substance P from brain contains a cholecystokinin-like peptide.

1. New peptide in the vertebrate CNS reacting with antigastrin antibodies.

2. [Substance P, a polypeptide from the intestine and the brain, with depressive, hyperalgesic and morphine antagonist effects on CNS].

3. High-sensitivity radioimmunoassay for substance P.

4. Demonstration of biological activity of brain gastrin-like peptidic material in the human: its relationship with the COOH-terminal octapeptide of cholecystokinin.

5. [Distribution of gut-centracting peptides in human brain].

6. [Active peptides in substance P preparations from cortex, globus pallidus and substantia nigra of human brains].

7. Pharmacologically active peptides in extracts from cortical and subcortical tissues of human and bovine brain.

8. Mode of action of cholecystokinin and related peptides on gallbladder muscle.

9. Immunochemical evidence of cholecystokinin-like peptides in brain.

10. Localisation of gastrins to neuro- and adenohypophysis.

1. The release of rat intestinal cholecystokinin after oral trypsin inhibitor measured by bio-assay.