Literature DB >> 7327190

Chemical structure and pharmacokinetics of 99mTc-labelled aminomethane diphosphonic acid derivatives.

S Unterspann, W Finck.   

Abstract

99mTc-labelled derivatives of aminomethane diphosphonic acid, general formula: R1R2N-CR3 [PO(OH)2]2, as well as hydroxyethane diphosphonic acid and hydroxypropane monophosphonic acid were investigated with regard to their suitability for skeleton scintigraphy. Bone accumulation was related to chemical structure. It was concluded from the experiments that compounds able to form enols are accumulated to a higher degree and that big substituents influence the affinity to bone negatively by steric hindrance.

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Year:  1981        PMID： 7327190     DOI： 10.1007/bf00255886

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  7 in total

1.  Technetium-99m-labeled stannous ethane-1-hydroxy-1 1-diphosphonate: a new bone scanning agent.

Authors:  Y Yano; J McRae; D C Van Dyke; H O Anger
Journal:  J Nucl Med       Date:  1973-02       Impact factor: 10.057

2.  New bone scanning agent: 99m Tc-labeled 1-hydroxy-ethylidene-1, 1-disodium phosphonate.

Authors:  F P Castronovo; R J Callahan
Journal:  J Nucl Med       Date:  1972-11       Impact factor: 10.057

3.  Technetium-99m-methylene diphosphonate--a superior agent for skeletal imaging: comparison with other technetium complexes.

Authors:  G Subramanian; J G McAfee; R J Blair; F A Kallfelz; F D Thomas
Journal:  J Nucl Med       Date:  1975-08       Impact factor: 10.057

4.  Experimental examinations on the suitability of organoaminomethane-bis-phosphonic acids for bone-scintigraphy by means of Tc-99m in animals.

Authors:  S Unterspann
Journal:  Eur J Nucl Med       Date:  1976-08-12

5.  A study of the relationship between chemical structure and bone localization of Tc-99m diphosphonic acids: concise communication.

Authors:  T S Wang; G E Mojdehi; R A Fawwaz; P M Johnson
Journal:  J Nucl Med       Date:  1979-10       Impact factor: 10.057

6.  Bone accumulation of the Tc-99m complex of carbamyl phosphate and its analogs.

Authors:  P Hosain; R P Spencer; K J Ahlquist; P K Sripada
Journal:  J Nucl Med       Date:  1978-05       Impact factor: 10.057

7.  Method for the synthesis of 1-hydroxy-ethylidene-1, 1-disodium phosphonate (HEDSPA): a skeletal seeking radiopharmaceutical after labeling with 99mTc.

Authors:  F P Castronovo
Journal:  J Nucl Med       Date:  1974-02       Impact factor: 10.057
  7 in total

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