Literature DB >> 7326018

Cellular localization of neuraminidases in cultured human fibroblasts.

M Zeigler, G Bach.   

Abstract

The cellular localization of glycoprotein and ganglioside sialidases in normal and I-cell-disease cultured fibroblasts has been investigated. Cellular organelles have been separated on a colloidal silica gradient. The subcellular distribution of these enzymes indicated that the glycoprotein sialidase is mainly a lysosomal hydrolase, whereas the ganglioside sialidase is primarily located in the plasma membranes. The latter isoenzymes is tightly bound to these membranes and thus could not be extracted by homogenization in the presence of Triton X-100. The interpretation of this finding and its relation to the pathochemistry of sialidase-deficient disorders is discussed.

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Year:  1981        PMID： 7326018      PMCID： PMC1163295          DOI： 10.1042/bj1980505

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  26 in total

1.  Neuraminidase activity in mammalian organs.

Authors:  R CARUBELLI; R E TRUCCO; R CAPUTTO
Journal:  Biochim Biophys Acta       Date:  1962-06-18

2.  Studies on brain cytosol neuraminadase. I. Isolation and partial characterization of two forms of the enzyme from pig brain.

Authors:  B Venerando; G Tettamanti; B Cestaro; V Zambotti
Journal:  Biochim Biophys Acta       Date:  1975-10-22

3.  Sialidase activity in transformed cells.

Authors:  C L Schengrund; R N Lausch; A Rosenberg
Journal:  J Biol Chem       Date:  1973-06-25       Impact factor: 5.157

4.  Cytidine 5'-monophosphosialic acid hydrolase. Subcellular location and properties.

Authors:  E L Kean; K J Bighouse
Journal:  J Biol Chem       Date:  1974-12-25       Impact factor: 5.157

5.  Enzymatic hydrolysis of sphingolipids. VII. Hydrolysis of gangliosides by a neuraminidase from calf brain.

Authors:  Z Leibovitz; S Gatt
Journal:  Biochim Biophys Acta       Date:  1968-01-10

6.  Parallelism of subcellular location of major particulate neuraminidase and gangliosides in rabbit brain cortex.

Authors:  G Tettamanti; A Preti; A Lombardo; F Bonali; V Zambotti
Journal:  Biochim Biophys Acta       Date:  1973-06-21

7.  Intracellular location and properties of bovine brain sialidase.

Authors:  C L Schengrund; A Rosenberg
Journal:  J Biol Chem       Date:  1970-11-25       Impact factor: 5.157

8.  Cell contact-dependent ganglioside changes in mouse 3T3 gibroblasts and a suppressed sialidase activity on cell contact.

Authors:  G Yogeeswaran; S Hakomori
Journal:  Biochemistry       Date:  1975-05-20       Impact factor: 3.162

9.  The metabolism of Tay-Sachs ganglioside: catabolic studies with lysosomal enzymes from normal and Tay-Sachs brain tissue.

Authors:  J F Tallman; W G Johnson; R O Brady
Journal:  J Clin Invest       Date:  1972-09       Impact factor: 14.808

10.  Increased levels of sialic acid associated with a sialidase deficiency in I-cell disease (mucolipidosis II) fibroblasts.

Authors:  G H Thomas; G E Tiller; L W Reynolds; C S Miller; J W Bace
Journal:  Biochem Biophys Res Commun       Date:  1976-07-12       Impact factor: 3.575
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  9 in total

1.  Mucolipidosis type IV: abnormal transport of lipids to lysosomes.

Authors:  R Bargal; G Bach
Journal:  J Inherit Metab Dis       Date:  1997-09       Impact factor: 4.982

2.  Regulation of liver cell ganglioside composition by extracellular fluid viscosity.

Authors:  S Yedgar; N Reisfeld-Granot; B A Sela
Journal:  Lipids       Date:  1986-10       Impact factor: 1.880

3.  Cellular localization and substrate specificity of isoelectric forms of human liver neuraminidase activity.

Authors:  J Spaltro; J A Alhadeff
Journal:  Biochem J       Date:  1987-01-01       Impact factor: 3.857

4.  Specificity studies on the oligosaccharide neuraminidase of human fibroblasts.

Authors:  K Mendla; M Cantz
Journal:  Biochem J       Date:  1984-03-01       Impact factor: 3.857

5.  Properties of endogenous, membrane-associated sialidase activity (N-acetylneuraminidase) of the goldfish visual system.

Authors:  K C Leskawa; B W Agranoff
Journal:  Neurochem Res       Date:  1983-01       Impact factor: 3.996

6.  Phospholipids accumulation in mucolipidosis IV cultured fibroblasts.

Authors:  R Bargal; G Bach
Journal:  J Inherit Metab Dis       Date:  1988       Impact factor: 4.982

7.  Ganglioside GM3 sialidase activity in fibroblasts of normal individuals and of patients with sialidosis and mucolipidosis IV. Subcellular distribution and and some properties.

Authors:  M Lieser; E Harms; H Kern; G Bach; M Cantz
Journal:  Biochem J       Date:  1989-05-15       Impact factor: 3.857

8.  Cell-contact mediated modulation of the sialylation of contactinhibin.

Authors:  R J Wieser; C E Baumann; F Oesch
Journal:  Glycoconj J       Date:  1995-10       Impact factor: 2.916

9.  Characterization of human placental neuraminidases. Stability, substrate specificity and molecular weight.

Authors:  D McNamara; G Beauregard; H V Nguyen; D L Yan; M Bélisle; M Potier
Journal:  Biochem J       Date:  1982-08-01       Impact factor: 3.857
  9 in total

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