Literature DB >> 7325997

Effects of liver damage on ketone-body production and nitrogen balance in starved rats.

J P Flatt, J M Quail.   

Abstract

The metabolic effects of intraperitoneal administration of carbon tetrachloride (1ml/kg) were studied in starved rats. The most notable change in circulating substrates was an 80% fall in ketone-body concentrations, which was associated with the doubling of urinary nitrogen losses. The results demonstrate the importance of starvation ketosis in permitting fat mobilization to decrease effectively protein losses during starvation.

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Year:  1981        PMID: 7325997      PMCID: PMC1163232          DOI: 10.1042/bj1980227

Source DB:  PubMed          Journal:  Biochem J        ISSN: 0264-6021            Impact factor:   3.857


  15 in total

1.  Microdetermination of long-chain fatty acids in plasma and tissues.

Authors:  V P DOLE; H MEINERTZ
Journal:  J Biol Chem       Date:  1960-09       Impact factor: 5.157

2.  Effect of nicotinamide on carbohydrate metabolism in the rat liver during starvation.

Authors:  H Talke; K P Maier; M Kersten; W Gerok
Journal:  Eur J Clin Invest       Date:  1973-12       Impact factor: 4.686

Review 3.  Rate control of the tricarboxylic acid cycle.

Authors:  H A Krebs
Journal:  Adv Enzyme Regul       Date:  1970

Review 4.  Starvation in man.

Authors:  G F Cahill
Journal:  N Engl J Med       Date:  1970-03-19       Impact factor: 91.245

5.  Prevention by cystamine of liver necrosis and early biochemical alterations induced by carbon tetrachloride.

Authors:  J A Castro; E V Cignoli; C R De Castro; O M De Fenos
Journal:  Biochem Pharmacol       Date:  1972-01       Impact factor: 5.858

6.  Critical variables in the radioimmunoassay of serum insulin using the double antibody technic.

Authors:  J S Soeldner; D Slone
Journal:  Diabetes       Date:  1965-12       Impact factor: 9.461

Review 7.  The matabolic fuel regulatory system: implications for protein-sparing therapies during caloric deprivation and disease.

Authors:  J P Flatt; G L Blackburn
Journal:  Am J Clin Nutr       Date:  1974-02       Impact factor: 7.045

8.  Metabolic studies in experimental liver disease resulting from D(+)-galactosamine administration.

Authors:  C O Record; K G Alberti; D H Williamson
Journal:  Biochem J       Date:  1972-11       Impact factor: 3.857

9.  Turnover rates of ketone bodies in normal, starved and alloxan-diabetic rats.

Authors:  M W Bates; H A Krebs; D H Williamson
Journal:  Biochem J       Date:  1968-12       Impact factor: 3.857

10.  Effect of insulin and acute diabetes on plasma FFA and ketone bodies in the fasting rat.

Authors:  F A Bieberdorf; S S Chernick; R O Scow
Journal:  J Clin Invest       Date:  1970-09       Impact factor: 14.808

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