Literature DB >> 7325988

Identification of aspirinase with one of the carboxylesterases requiring a thiol group.

K N White, D B Hope.   

Abstract

Aspirin-hydrolysing activity in guinea-pig liver is located mainly in the microsomal fraction. This activity was found by electrophoresis to be due to a single carboxylesterase band, out of 12 bands revealed with alpha-naphthyl acetate as substrate. The activity is inhibited completely and irreversibly by the carboxylesterase inhibitor bis-(-4-nitrophenyl) hydrogen phosphate, and also by thiol-blocking reagents.

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Year:  1981        PMID： 7325988      PMCID： PMC1163196          DOI： 10.1042/bj1970771

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  A simple procedure for the isolation of rat liver microsomes.

Authors:  S A. Kamath; F A. Kummerow; K Ananth Narayan
Journal:  FEBS Lett       Date:  1971-09-15       Impact factor: 4.124

2.  Isoenzymes of soluble and membrane-bound acetylcholinesterase in boine splanchnic nerve and adrenal medulla.

Authors:  I W Chubb; A D Smith
Journal:  Proc R Soc Lond B Biol Sci       Date:  1975-11-18

3.  DISC ELECTROPHORESIS. II. METHOD AND APPLICATION TO HUMAN SERUM PROTEINS.

Authors:  B J DAVIS
Journal:  Ann N Y Acad Sci       Date:  1964-12-28       Impact factor: 5.691

4.  Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.

Authors:  C DE DUVE; B C PRESSMAN; R GIANETTO; R WATTIAUX; F APPELMANS
Journal:  Biochem J       Date:  1955-08       Impact factor: 3.857

5.  Influence of the route of administration on the area under the plasma concentration-time curve.

Authors:  P A Harris; S Riegelman
Journal:  J Pharm Sci       Date:  1969-01       Impact factor: 3.534

6.  [Phosphoric acid-bis-(p-nitro-phenylester), a new inhibitor of microsomal carboxylesterases].

Authors:  E Heymann; K Krisch
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1967-06

7.  Selective inhibition of rat liver carboxylesterases by various organophosphorus diesters in vivo and in vitro.

Authors:  E Brandt; E Heymann; R Mentlein
Journal:  Biochem Pharmacol       Date:  1980-07-01       Impact factor: 5.858

8.  Investigations on the functional role of rat liver carboxylesterase isoenzymes.

Authors:  R Arndt; H E Schlaak; D Uschtrin; D Südi; K Michelssen; W Jungle
Journal:  Hoppe Seylers Z Physiol Chem       Date:  1978-05

9.  Acetylsalicylate hydrolase of rabbit gastric mucosa. Isolation and purification.

Authors:  J G Spenney; R M Nowell
Journal:  Drug Metab Dispos       Date:  1979 Jul-Aug       Impact factor: 3.922

10.  A simultaneous-coupling azo dye method for the quantitative assay of esterase using alpha-naphthyl acetate as substrate.

Authors:  K J Johnston; A E Ashford
Journal:  Histochem J       Date:  1980-03
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  3 in total

1.  Purification and characterization of guinea-pig liver microsomal deacetylase involved in the deacetylation of the O-glucoside of N-hydroxyacetanilide.

Authors:  M Suzuki-Kurasaki; T Yoshioka; T Uematsu
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Purification and properties of an esterase from the yeast Saccharomyces cerevisiae and identification of the encoding gene.

Authors:  G Degrassi; L Uotila; R Klima; V Venturi
Journal:  Appl Environ Microbiol       Date:  1999-08       Impact factor: 4.792

Review 3.  Clinical significance of esterases in man.

Authors:  F M Williams
Journal:  Clin Pharmacokinet       Date:  1985 Sep-Oct       Impact factor: 6.447
  3 in total

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