Literature DB >> 7325803

Morphology of early changes in liver carcinogenesis induced by methapyrilene.

H M Reznik-Schüller, W Lijinsky.   

Abstract

Two weeks of treatment with the liver carcinogen methapyrilene induced a significant increase in mitochondria of periportal hepatocytes in F344 rats. Administration of [3H]-methapyrilene hydrochloride resulted in a pronounced concentration of bound radioactivity in the periportal hepatocytes, with mitochondria being the principal site of intracellular binding. The nuclei of the liver cells were unlabeled.

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Year:  1981        PMID： 7325803     DOI： 10.1007/bf00352075

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  5 in total

1.  Electron microscopic autoradiography of the pancreas in the hamster treated with tritiated N-nitroso-2,6-dimethylmorpholine.

Authors:  H M Reznik-Schüller; W Lijinsky; B F Hague
Journal:  Cancer Res       Date:  1980-07       Impact factor: 12.701

2.  Ultrastructure of liver tumors induced in F344 rats by methapyrilene.

Authors:  H M Reznik-Schüller; M D Reuber
Journal:  J Environ Pathol Toxicol Oncol       Date:  1986 Sep-Dec       Impact factor: 3.567

3.  Liver tumors induced in rats by oral administration of the antihistaminic methapyrilene hydrochloride.

Authors:  W Lijinsky; M D Reuber; B N Blackwell
Journal:  Science       Date:  1980-08-15       Impact factor: 47.728

4.  In vivo autoradiography and nitrosoheptamethyleneimine carcinogenesis in hamsters.

Authors:  H Reznik-Schüller; W Lijinsky
Journal:  Cancer Res       Date:  1979-01       Impact factor: 12.701

5.  A morphometric study of the pulmonary Clara cell in normal and nitrosoheptamethyleneimine-treated European hamsters.

Authors:  H Reznik-Schüller; B F Hague
Journal:  Exp Pathol (Jena)       Date:  1980
  5 in total
  4 in total

1.  Methaphenilene, an analogue of the antihistaminic methapyrilene, is a "peroxisome proliferator".

Authors:  H M Reznik-Schüller; W Lijinsky
Journal:  Arch Toxicol       Date:  1983-02       Impact factor: 5.153

2.  Gene expression analysis of the hepatotoxicant methapyrilene in primary rat hepatocytes: an interlaboratory study.

Authors:  Johanna M Beekman; Franziska Boess; Heinrich Hildebrand; Arno Kalkuhl; Laura Suter
Journal:  Environ Health Perspect       Date:  2006-01       Impact factor: 9.031

3.  Induction of peroxisome proliferation and hepatic tumours in C57BL/6N mice by ciprofibrate, a hypolipidaemic compound.

Authors:  M S Rao; R S Dwivedi; V Subbarao; J K Reddy
Journal:  Br J Cancer       Date:  1988-07       Impact factor: 7.640

4.  B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals.

Authors:  Alistair C Leitch; Philip M E Probert; James A Shayman; Stephanie K Meyer; George E N Kass; Matthew C Wright
Journal:  Toxicology       Date:  2017-05-26       Impact factor: 4.221
  4 in total

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