Literature DB >> 7322838

Electrogenic Na pump evidenced by injecting various Na salts into the isolated A-V node cells of rabbit heart.

Y Kurachi, A Noma, H Irisawa.   

Abstract

Electrogenicity of the Na pump was confirmed by injecting Na salts into a small cluster of A-V node cells. Injection of Na glutamate or Na acetate induced marked hyperpolarization, accompanying with cessation of spontaneous activity. The hyperpolarization exceeded EK in 27 mM K Tyrode solution and was inhibited by 10(-5) M strophanthidin. Injection of NaCl or NaI depolarized the membrane. These data showed that inward-going current carried by the injected anion antagonized the outward-going pump current and thus determined the net effect of the injection.

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Year:  1981        PMID： 7322838     DOI： 10.1007/bf00584587

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  8 in total

1.  EFFECTS PRODUCED ON INHIBITORY POSTSYNAPTIC POTENTIALS BY THE COUPLED INJECTIONS OF CATIONS AND ANIONS INTO MOTONEURONS.

Authors:  J ECCLES; R M ECCLES; M ITO
Journal:  Proc R Soc Lond B Biol Sci       Date:  1964-05-19

2.  AN ELECTROGENIC SODIUM PUMP IN SNAIL NERVE CELLS.

Authors:  G A KERKUT; R C THOMAS
Journal:  Comp Biochem Physiol       Date:  1965-01

Review 3.  Characteristics of active Na transport in intact cardiac cells.

Authors:  H G Glitsch
Journal:  Am J Physiol       Date:  1979-02

Review 4.  Electrogenic sodium pump in nerve and muscle cells.

Authors:  R C Thomas
Journal:  Physiol Rev       Date:  1972-07       Impact factor: 37.312

5.  Steady state contribution of the Na, K-pump to the membrane potential in identified neurons of a terrestrial snail, Helix pomatia.

Authors:  G R Christoffersen
Journal:  Acta Physiol Scand       Date:  1972-12

6.  On the electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations.

Authors:  H P Rang; J M Ritchie
Journal:  J Physiol       Date:  1968-05       Impact factor: 5.182

7.  Spontaneously active cells isolated from the sino-atrial and atrio-ventricular nodes of the rabbit heart.

Authors:  J Taniguchi; S Kokubun; A Noma; H Irisawa
Journal:  Jpn J Physiol       Date:  1981

8.  Membrane permeability during low potassium depolarization in sheep cardiac Purkinje fibers.

Authors:  C O Lee; H A Fozzard
Journal:  Am J Physiol       Date:  1979-09
  8 in total
  2 in total

1.  Inhibition of the Na pump--a mechanism in the genesis of cardiac arrhythmias.

Authors:  H G Glitsch
Journal:  Basic Res Cardiol       Date:  1984 Nov-Dec       Impact factor: 17.165

2.  The effects of intracellular protons on the electrical activity of single ventricular cells.

Authors:  Y Kurachi
Journal:  Pflugers Arch       Date:  1982-09       Impact factor: 3.657
  2 in total

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