Double screening test at 8th and 12th hour of overnight fasting for a better classification of idiopathic hyperlipidemias. Large scale study of 505 tests.

Total blood cholesterol, plasma triglycerides, and lipoprotein electrophoresis have been studied 8 and 12 hours after a standard meal. In controls and in familial hypercholesterolemia, plasma triglycerides were normal at 8th and 12th hour of fasting. In mixed hyperlipidemia, as in endogenous hypertriglyceridemia, plasma triglycerides were abnormally high at the 8th hour of fasting. Difference of 8th-12th hour triglycerides levels was greater in these two groups than in controls and in familial hypercholesterolemia. These results suggest than the 8th jour value will rectify a mistaken classification or detect a latent hyperlipidemia.