Literature DB >> 7318161

The effect of calcium antagonist, nifedipine in exercise-induced asthma.

K R Patel.   

Abstract

The effect of nifedipine was studied in fifteen patients with exercise-induced asthma. Nifedipine inhibited the exercise-induced fall in FEV1 almost completely in four patients, offered partial protection in a further nine patients and had no effect in the remaining two patients. It is suggested that mediator release which is dependent on free calcium ions may play an important role in exercise-induced asthma and calcium antagonists may inhibit post-exercise bronchoconstriction by their blocking effect on calcium channels of the mast cells.

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Year:  1981        PMID： 7318161     DOI： 10.1111/j.1365-2222.1981.tb01615.x

Source DB:  PubMed          Journal:  Clin Allergy        ISSN： 0009-9090


  18 in total

1.  Efficacy of calcium channel blockers as maintenance therapy for asthma.

Authors:  Mary Ann Twiss; Eloise Harman; Sarah Chesrown; Leslie Hendeles
Journal:  Br J Clin Pharmacol       Date:  2002-03       Impact factor: 4.335

2.  The effect of diltiazem, a calcium channel blocker, in asthmatic patients.

Authors:  Francesca Quintieri; Antonella D'Ambrosio; Alessandra Bachetoni
Journal:  Br J Clin Pharmacol       Date:  2002-12       Impact factor: 4.335

Review 3.  Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.

Authors:  E M Sorkin; S P Clissold; R N Brogden
Journal:  Drugs       Date:  1985-09       Impact factor: 9.546

Review 4.  Calcium channel blockers and asthma.

Authors:  S Y So; M Ip; W K Lam
Journal:  Lung       Date:  1986       Impact factor: 2.584

Review 5.  Heterogeneity of calcium channels in mast cells and basophils and the possible relevance to pathophysiology of lung diseases: a review.

Authors:  N Chand; J L Perhach; W Diamantis; R D Sofia
Journal:  Agents Actions       Date:  1986-03

Review 6.  Clinical studies with calcium antagonists in asthma.

Authors:  P J Barnes
Journal:  Br J Clin Pharmacol       Date:  1985       Impact factor: 4.335

Review 7.  Anatomy and physiology of the nose--pathophysiologic alterations in allergic rhinitis.

Authors:  N Mygind; A Anggård
Journal:  Clin Rev Allergy       Date:  1984-08

8.  Influence of diltiazem on bronchoconstriction induced by cold air breathing during exercise.

Authors:  H Magnussen; V Hartmann; G Reuss
Journal:  Thorax       Date:  1984-08       Impact factor: 9.139

9.  Inhibition of exercise-induced asthma by nifedipine: a dose-response study.

Authors:  P Rafferty; J G Varley; J S Edwards; S T Holgate
Journal:  Br J Clin Pharmacol       Date:  1987-10       Impact factor: 4.335

10.  The obligatory role of calcium in the development of antigen-induced airway hyperreactivity to cold provocation in the rat isolated trachea.

Authors:  N Chand; W Diamantis; R D Sofia
Journal:  Br J Pharmacol       Date:  1987-05       Impact factor: 8.739
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