Literature DB >> 73180

Mouse cytolytic T lymphocytes induced by xenogeneic rat stimulator cells exhibit specificity for H-2 complex alloantigens.

S J Burakoff, S E Ratnofsky, B Benacerraf.   

Abstract

When mouse spleen cells were stimulated with irradiated xenogeneic, allogeneic, or trinitrophenyl-modified syngeneic lymphoid cells, the strongest cytolytic response was induced by alloantigens. Mouse cytolytic T lymphocytes generated to rat lymphoid cells demonstrated specificity for the immunizing rat strain, but extensive lysis of allogeneic target cells from certain mouse strains was also observed. Cold target inhibition studies indicated that separate clones of xenoantigen-induced cytolytic T lymphocytes lysed each of the allogeneic murine targets. [3H]Thymidine suicide of the effector cells generated to the rat stimulators revealed that only some of all potentially reactive mouse cytolytic T lymphocyte precursors with specificity for a given allogeneic target are activated by the stimulation with rat cells. This evidence that xenoantigens induce alloreactive cytolytic T lymphocyte receptor repertoire is directed at variants of autologous major histocompatibility complex antigens.

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Year:  1977        PMID： 73180      PMCID： PMC431988          DOI： 10.1073/pnas.74.10.4572

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  12 in total

1.  Inhibition of cell-mediated cytolysis of trinitrophenyl-derivatized target cells by alloantisera directed to the products of the K and D loci of the H-2 complex.

Authors:  S J Burakoff; R N Germain; M E Dorf; B Benacerrah
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205

Review 2.  The somatic generation of immune recognition.

Authors:  N K Jerne
Journal:  Eur J Immunol       Date:  1971-01       Impact factor: 5.532

3.  Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.

Authors:  M J Bevan
Journal:  Nature       Date:  1975-07-31       Impact factor: 49.962

4.  Cytolytic thymus-derived lymphocytes specific for allogeneic stimulator cells crossreact with chemically modified syngeneic cells.

Authors: 
Journal:  Proc Natl Acad Sci U S A       Date:  1977-03       Impact factor: 11.205

5.  Specificity of human lymphocytes proliferating in response to allogeneic and xenogeneic cells in vitro.

Authors:  H Hirschberg; B Rankin; E Thorsby
Journal:  Transplantation       Date:  1974-06       Impact factor: 4.939

6.  Human lymphocytes recognise mouse alloantigens.

Authors:  K F Lindahl; F H Bach
Journal:  Nature       Date:  1975-04-17       Impact factor: 49.962

Review 7.  Cell-mediated cytotoxicity, allograft rejection, and tumor immunity.

Authors:  J C Cerottini; K T Brunner
Journal:  Adv Immunol       Date:  1974       Impact factor: 3.543

8.  Role of the murine major histocompatibility complex in the specificity of in vitro T-cell-mediated lympholysis against chemically-modified autologous lymphocytes.

Authors:  G M Shearer; T G Rehn; A M Schmitt-Verhulst
Journal:  Transplant Rev       Date:  1976

9.  Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity.

Authors:  P C Doherty; R V Blanden; R M Zinkernagel
Journal:  Transplant Rev       Date:  1976

10.  Cross-reactive lysis of trinitrophenyl (TNP)-derivatized H-2 incompatible target cells by cytolytic T lymphocytes generated against syngeneic TNP spleen cells.

Authors:  S J Burakoff; R N Germain; B Benacerraf
Journal:  J Exp Med       Date:  1976-12-01       Impact factor: 14.307
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  9 in total

1.  The receptor specificity of alloreactive T cells. Distinction between stimulator K, I, and D region products and degeneracy of third-party H-2 recognition by low-affinity T cells.

Authors:  Z A Nagy; B E Elliott
Journal:  J Exp Med       Date:  1979-12-01       Impact factor: 14.307

2.  Activity of the EBNA1 promoter associated with lytic replication (Fp) in Epstein-Barr virus associated disorders.

Authors:  A A Brink; C J Meijer; J M Nicholls; J M Middeldorp; A J van den Brule
Journal:  Mol Pathol       Date:  2001-04

3.  Induction of secondary cytotoxic T lymphocytes by purified HLA-A and HLA-B antigens reconstituted into phospholipid vesicles.

Authors:  V H Engelhard; J L Strominger; M Mescher; S Burakoff
Journal:  Proc Natl Acad Sci U S A       Date:  1978-11       Impact factor: 11.205

4.  Recognition of HLA-B27 by mouse cytotoxic T-cell clones: a transgenic mouse model.

Authors:  M Reboul; B Frangoulis; A Rocca; L Degos; M Pla
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

5.  Differential expression of RT1 class II genes in fibroblast cell lines: recognition by allogeneic and xenogeneic T lymphocytes.

Authors:  S J Eccles; H S Teh; A G Diamond; W R McMaster
Journal:  Immunology       Date:  1986-09       Impact factor: 7.397

6.  Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response.

Authors:  M J Irwin; W R Heath; L A Sherman
Journal:  J Exp Med       Date:  1989-10-01       Impact factor: 14.307

7.  Genetic control of cytolytic t-lymphocyte responses. II. The role of the host genotype in parental leads to F1 radiation chimeras in the control of the specificity of cytolytic T-lymphocyte responses to trinitrophenyl-modified syngeneic cells.

Authors:  P Billings; S J Burakoff; M E Dorf; B Benacerraf
Journal:  J Exp Med       Date:  1978-08-01       Impact factor: 14.307

8.  The biologic significance of alloreactivity. The ontogeny of T-cell sets specific for alloantigens or modified self antigens.

Authors:  S J Burakoff; R Finberg; L Glimcher; F Lemonnier; B Benacerraf; H Cantor
Journal:  J Exp Med       Date:  1978-11-01       Impact factor: 14.307

9.  Species specificity and augmentation of responses to class II major histocompatibility complex molecules in human CD4 transgenic mice.

Authors:  E Barzaga-Gilbert; D Grass; S K Lawrance; P A Peterson; E Lacy; V H Engelhard
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307
  9 in total

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