| Literature DB >> 7317243 |
Abstract
The theoretical basis of a pharmacokinetic method to obtain rapidly and maintain a steady plasma concentration of an i. v. drug is described. Computer simulations of morphine disposition in man, using pharmacokinetic constants obtained from the literature, are provided as examples of steady-state dose regimens. The usefulness and potential limitations of the method are discussed.Entities:
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Year: 1981 PMID： 7317243 DOI： 10.1093/bja/53.12.1247
Source DB: PubMed Journal: Br J Anaesth ISSN： 0007-0912 Impact factor: 9.166