Literature DB >> 7316759

A case of fatal poisoning by rifampicin.

T A Plomp, H J Battista, H Unterdorfer, W C van Ditmarsch, R A Maes.   

Abstract

The toxicologic findings of a fatal poisoning with rifampicin (Rimactan) are presented. The concentration of rifampicin and its two major metabolites 25-desacetylrifampicin and 3-formylrifamycin in post-mortem blood, urine, bile and liver at about 10 h after ingestion of 14-15 g was determined using a high-performance liquid chromatographic method. The results of the toxicological analyses were compared with findings in fatal and non-fatal intoxications and after therapeutic administration of the drug. Possible explanation for the fatal outcome is given.

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Year:  1981        PMID： 7316759     DOI： 10.1007/bf00319652

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  10 in total

1.  [Separation, determination and pharmacokinestics of rifampicin and its biotransformation products].

Authors:  K Winsel; H Iwainsky; E Werner; H Eule
Journal:  Pharmazie       Date:  1976       Impact factor: 1.267

2.  Rifampicin overdosage--"the red man syndrome.".

Authors:  R W Newton; A R Forrest
Journal:  Scott Med J       Date:  1975-03       Impact factor: 0.729

3.  [Unsuccessful suicide attempt with rifampicin].

Authors:  N Konietzko; H Burkhardt
Journal:  Pneumonologie       Date:  1971

4.  Rifampicin: a new rifamycin. 3. Absorption, distribution, and elimination in man.

Authors:  S Furesz; R Scotti; R Pallanza; E Mapelli
Journal:  Arzneimittelforschung       Date:  1967-05

5.  Rifampicin desacetylation in the human organism.

Authors:  N Maggi; S Furesz; R Pallanza; G Pelizza
Journal:  Arzneimittelforschung       Date:  1969-04

6.  Fatal rifampicin-ethambutol overdosage.

Authors:  D B Jack; J Knepil; W D McLay; R Fergie
Journal:  Lancet       Date:  1978-11-18       Impact factor: 79.321

7.  Quantitative assay of rifampicin and three of its metabolites in human plasma, urine and saliva by high-performance liquid chromatography.

Authors:  J B Lecaillon; N Febvre; J P Metayer; C Souppart
Journal:  J Chromatogr       Date:  1978-03-01

8.  Suicide by rifampin overdose.

Authors:  R O Broadwell; S D Broadwell; P B Comer
Journal:  JAMA       Date:  1978-11-17       Impact factor: 56.272

9.  Rifampin: a suicidal dose.

Authors:  S Meisel; R Brower
Journal:  Ann Intern Med       Date:  1980-02       Impact factor: 25.391

10.  Studies on pharmacokinetics of rifampicin in the body of patients with pulmonary tuberculosis.

Authors:  I Pawlowska; T Pniewski
Journal:  Arzneimittelforschung       Date:  1979
  10 in total
  4 in total

Review 1.  A review of the Redman syndrome and rifampicin overdosage.

Authors:  M R Holdiness
Journal:  Med Toxicol Adverse Drug Exp       Date:  1989 Nov-Dec

2.  Oral pyridoxine can substitute for intravenous pyridoxine in managing patients with severe poisoning with isoniazid and rifampicin fixed dose combination tablets: a case report.

Authors:  M D S A Dilrukshi; C A P Ratnayake; C A Gnanathasan
Journal:  BMC Res Notes       Date:  2017-08-08

3.  In Vitro Assessment of the Interaction Potential of Ocimum basilicum (L.) Extracts on CYP2B6, 3A4, and Rifampicin Metabolism.

Authors:  Saneesh Kumar; Patrick J Bouic; Bernd Rosenkranz
Journal:  Front Pharmacol       Date:  2020-04-30       Impact factor: 5.810

4.  Fatal poisoning by isoniazid and rifampicin.

Authors:  A Sridhar; Y Sandeep; C Krishnakishore; P Sriramnaveen; Y Manjusha; V Sivakumar
Journal:  Indian J Nephrol       Date:  2012-09
  4 in total

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