Literature DB >> 7315413

Effect of vasoactive intestinal polypeptide (VIP) upon myometrial blood flow in non-pregnant rabbit.

B Ottesen, J Fahrenkrug.   

Abstract

Vasoactive intestinal polypeptide (VIP) containing nerve fibres have previously been demonstrated in the female genital tract of several mammalian species including the rabbit. These nerve fibres seemingly innervate vascular and non-vascular smooth muscle. For that reason we investigated the dose-relationship between VIP (5, 50, 500 pmol . min-1 . kg-1) and myometrial blood flow (MBF) using Xenon-133 washout technique. VIP increased MBF dose-dependently. VIP was on molar base 100 times more potent than acetylcholine. The action of VIP seems to be direct on vascular smooth muscle rather than mediated by other neurotransmitters, because the MBF increase was not antagonized by atropine, adrenergic blocking agents or naloxone. These findings make it likely that VIP plays a role in the local nervous control of myometrial blood flow.

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Year:  1981        PMID： 7315413     DOI： 10.1111/j.1748-1716.1981.tb06804.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  10 in total

1.  Comparative distribution of neuropeptide tyrosine-, vasoactive intestinal polypeptide-, substance P-immunoreactive, acetylcholinesterase-positive and noradrenergic nerves in the reproductive tract of the female rat.

Authors:  R E Papka; J P Cotton; H H Traurig
Journal:  Cell Tissue Res       Date:  1985       Impact factor: 5.249

2.  Peptidergic innervation of the human and guinea pig uterus.

Authors:  D Heinrich; M Reinecke; W G Forssmann
Journal:  Arch Gynecol       Date:  1986

3.  Changes in vasoactive intestinal polypeptide (VIP) levels in the rabbit oviduct at different hormonal stages. An immunohistochemical study.

Authors:  G Menghi; P Scocco; G Materazzi
Journal:  J Anat       Date:  1990-08       Impact factor: 2.610

4.  Peptide-immunoreactive nerves in the mammalian female genital tract.

Authors:  W M Huang; J Gu; M A Blank; J M Allen; S R Bloom; J M Polak
Journal:  Histochem J       Date:  1984-12

5.  Specific patterns of immunoreactivity in neuronal elements of the anterior major pelvic ganglion of the male guinea-pig.

Authors:  D Dhami; B S Mitchell
Journal:  J Anat       Date:  1991-06       Impact factor: 2.610

6.  Increased myometrial blood flow evoked by substance P.

Authors:  B R Gram; B Ottesen
Journal:  Pflugers Arch       Date:  1982-12       Impact factor: 3.657

7.  Immunohistochemical and biological evidence for a neuromodulator function of neuropeptide Y in the human oviduct.

Authors:  D Heinrich; M Reinecke; J F Gauwerky; W G Forssmann
Journal:  Arch Gynecol Obstet       Date:  1987       Impact factor: 2.344

8.  Pregnancy reduces noradrenaline but not neuropeptide levels in the uterine artery of the guinea-pig.

Authors:  M C Mione; J F Cavanagh; J Lincoln; P Milner; G Burnstock
Journal:  Cell Tissue Res       Date:  1990-03       Impact factor: 5.249

9.  Nervous release of vasoactive intestinal polypeptide from the feline uterus: pharmacological characteristics.

Authors:  J Fahrenkrug; B Ottesen
Journal:  J Physiol       Date:  1982-10       Impact factor: 5.182

10.  The assessment of vasoactive properties of CGRP and adrenomedullin in the microvasculature: a study using in vivo and in vitro assays in the mouse.

Authors:  Christina Tam; Susan D Brain
Journal:  J Mol Neurosci       Date:  2004       Impact factor: 3.444
  10 in total

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