| Literature DB >> 7314123 |
K Nagano, E Nakayama, H Oobayashi, T Yamada, H Adachi, T Nishizawa, H Ozawa, M Nakaichi, H Okuda, K Minami, K Yamazaki.
Abstract
An embryotoxicity study on ethylene glycol monomethyl ether (EGM) was carried out in ICR mice. They were given EGM daily at 6 dose levels (31.25, 62.5, 125, 250, 500 or 1000 mg/kg body wt) by gastric intubation on days 7 through 14 of gestation. On day 18 of gestation all fetuses were examined. Marked and dose-related embryotoxic effects were observed. Skeletal and gross anomalies, reduced fetal weight and fetal death were all observed at lower dosages of EGM, while marked leucopenia of the dams occurred at the highest dose.Entities:
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Year: 1981 PMID： 7314123 DOI： 10.1016/0300-483x(81)90040-8
Source DB: PubMed Journal: Toxicology ISSN： 0300-483X Impact factor: 4.221