Literature DB >> 7311563

Desensitization to the anticholinergic effects of atropine on isolated guinea pig ileum.

I Onnen, G Olive.   

Abstract

Guinea pig ileums in Tyrode solution develop a progressive desensitization to the effects of atropine (2-min exposure). This desensitization, followed carefully by a simplified method, is significant from the fourth hr. On the other hand, no desensitization develops to the effects of equilibrium exposure to atropine.

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Year:  1981        PMID: 7311563     DOI: 10.1016/0160-5402(81)90092-9

Source DB:  PubMed          Journal:  J Pharmacol Methods        ISSN: 0160-5402


  1 in total

1.  Non-specific, time-dependent desensitization of the vas deferens and anococcygeus preparations of the rat to alpha 1-adrenoceptor antagonists and atropine.

Authors:  I Onnen
Journal:  Br J Pharmacol       Date:  1984-09       Impact factor: 8.739

  1 in total

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