| Literature DB >> 7310830 |
R J Bochis, L E Olen, F S Waksmunski, H Mrozik, P Eskola, P Kulsa, G Wilks, J E Taylor, J R Egerton, D A Ostlind, G Olson.
Abstract
Anthelmintic efficacies of a series of 6-substituted methyl imidazo[1,2-alpha]pyridine-2-carbamates were compared to similarly substituted benzimidazole-2-carbamates. With only one exception, methyl 6-benzoylimidazo[1,2-alpha]pyridine-2-carbamate, both classes of compounds exhibited similar activity vs. Nematospiroides dubius in mice. Preliminary screening indicated methyl 6-(1,2,2-trichloroethenyl)imidazo[1,2-alpha]pyridine-2-carbamate to be the most potent derivative in the series. However, evaluation in sheep indicated that its anthelmintic spectrum was inferior to methyl 6-(phenylsulfinyl)imidazo[1,2-alpha]pyridine-2-carbamate.Entities:
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Year: 1981 PMID： 7310830 DOI： 10.1021/jm00144a030
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446