Literature DB >> 7310409

Rectal diazepam in the treatment of absence status: a pharmacodynamic study.

N Milligan, S Dhillon, A Richens, J Oxley.   

Abstract

Rectal administration of diazepam is highly effective in terminating absence status as judged by reduction of spike-wave activity in the EEG. Pharmacokinetic studies indicate that diazepam can have antiepileptic properties at serum levels well below those previously reported as being necessary to achieve a therapeutic effect.

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Year:  1981        PMID： 7310409      PMCID： PMC491177          DOI： 10.1136/jnnp.44.10.914

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  10 in total

1.  Plasma diazepam levels after single dose oral and intramuscular administration.

Authors:  J A Gamble; J W Dundee; R A Assaf
Journal:  Anaesthesia       Date:  1975-03       Impact factor: 6.955

2.  Plasma concentrations of diazepam and its metabolites after peroral, intramuscular, and rectal administration. Correlation between plasma concentration and sedatory effect of diazepam.

Authors:  J Kanto
Journal:  Int J Clin Pharmacol Biopharm       Date:  1975-12

3.  Plasma levels of diazepam after parenteral and rectal administration in children.

Authors:  S Agurell; A Berlin; H Ferngren; B Hellström
Journal:  Epilepsia       Date:  1975-06       Impact factor: 5.864

4.  Plasma-diazepam in infants after rectal administration in solution and by suppository.

Authors:  F U Knudsen
Journal:  Acta Paediatr Scand       Date:  1977-09

5.  Effects of different rates of absorption of two benzodiazepins on subjective and objective parameters. Significance for clinical use and risk of abuse.

Authors:  A Bliding
Journal:  Eur J Clin Pharmacol       Date:  1974       Impact factor: 2.953

6.  Serum concentrations of diazepam in subjects with epilepsy.

Authors:  H E Booker; G G Celesia
Journal:  Arch Neurol       Date:  1973-09

Review 7.  Benzodiazepines in the treatment of epilepsy. A review.

Authors:  T R Browne; J K Penry
Journal:  Epilepsia       Date:  1973-09       Impact factor: 5.864

8.  Absorption of diazepam in man following rectal and parenteral administration.

Authors:  I Magnussen; H R Oxlund; K E Alsbirk; E Arnold
Journal:  Acta Pharmacol Toxicol (Copenh)       Date:  1979-08

9.  Blood levels of diazepam (Valium) and N-desmethyl diazepam in the epileptic child. A preliminary report.

Authors:  A Viala; J P Cano; C Dravet; C A Tassinari; J Roger
Journal:  Psychiatr Neurol Neurochir       Date:  1971 Mar-Apr

10.  Rectal administration of diazepam in solution in the acute treatment of convulsions in infants and children.

Authors:  F U Knudsen
Journal:  Arch Dis Child       Date:  1979-11       Impact factor: 3.791
  10 in total
  4 in total

Review 1.  Pharmacokinetics of rectal drug administration, Part II. Clinical applications of peripherally acting drugs, and conclusions.

Authors:  E J van Hoogdalem; A G de Boer; D D Breimer
Journal:  Clin Pharmacokinet       Date:  1991-08       Impact factor: 6.447

Review 2.  Fosphenytoin: clinical pharmacokinetics and comparative advantages in the acute treatment of seizures.

Authors:  James H Fischer; Tejal V Patel; Patricia A Fischer
Journal:  Clin Pharmacokinet       Date:  2003       Impact factor: 6.447

Review 3.  Outpatient pharmacotherapy and modes of administration for acute repetitive and prolonged seizures.

Authors:  Heather Ravvin McKee; Bassel Abou-Khalil
Journal:  CNS Drugs       Date:  2015-01       Impact factor: 5.749

4.  A clinical trial of single dose rectal and oral administration of diazepam for the prevention of serial seizures in adult epileptic patients.

Authors:  N M Milligan; S Dhillon; A Griffiths; J Oxley; A Richens
Journal:  J Neurol Neurosurg Psychiatry       Date:  1984-03       Impact factor: 10.154
  4 in total

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