Literature DB >> 7309781

Antitumor activity of new nitrosoureas on Yoshida sarcoma ascites cells implanted into the colon wall of rats.

M Habs, H Reinbold, G Eisenbrand, S Bhide, S Goga-Ionescu, D Schmähl.   

Abstract

The chemotherapeutic activity of 12 newly synthesized nitrosoureas was compared in tests using Yoshida sarcoma ascites cells implanted into the wall of the descending colon in Sprague-Dawley rats. Cyclophosphamide and the nitrosoureas BCNU, MeCCNU, and chlorozotocin served as positive controls. Among the nitrosoureas tested, 1-(2-hydroxyethyl)-3-(2-chloroethyl)-3-nitrosourea (hydroxyethyl-CNU), chlorozotocin, 1-(2-chloroethyl)-1-nitroso-3-(4-morpholino) urea, 1-(2-chloroethyl)-1-nitroso-3-(1-piperidino) urea, 4-[1-(2-chloroethyl)-1-nitroso-3-[4-(2,6-dimethylmorpholino)] urea, and 1-(2-chloroethyl)-1-nitroso-3-(3,4-methylenedioxybenzyl) urea were found to be the most active compounds in this tumor model. Based on the present results, morpholino-CNU is considered the most promising compound among these newly synthesized BCNU analogues.

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Year:  1981        PMID： 7309781     DOI： 10.1007/bf00410114

Source DB:  PubMed          Journal:  J Cancer Res Clin Oncol        ISSN： 0171-5216            Impact factor:   4.553


  14 in total

Review 1.  Experimental carcinogenesis of antitumour drugs.

Authors:  D Schmähl; M Habs
Journal:  Cancer Treat Rev       Date:  1978-12       Impact factor: 12.111

2.  [Quantitative transplantation experiments with the Yoshida ascites sarcoma in rats].

Authors:  D SCHMAHL; R MECKE
Journal:  Z Krebsforsch       Date:  1955

3.  [Yoshida sarcoma in rat].

Authors:  H LETTRE
Journal:  Z Krebsforsch       Date:  1953

4.  Carcinogenic activity in Sprague-Dawley rats of 2-[3-(2-chloroethyl)-3-nitrosoureido]-D-gluco-pyranose (chlorozotocin).

Authors:  M Habs; G Eisenbrand; D Schmähl
Journal:  Cancer Lett       Date:  1979-12       Impact factor: 8.679

5.  [Quantitative studies in rats on the resistance of various organs to inoculated tumor cells].

Authors:  D Schmähl; H Osswald; L Prochotta
Journal:  Z Krebsforsch       Date:  1967

6.  Chronic toxicity and carcinogenicity of cytostatic N-nitroso-(2-chloroethyl) ureas after repeated intravenous application to rats.

Authors:  G Eisenbrand; M Habs
Journal:  Dev Toxicol Environ Sci       Date:  1980

7.  Studies on the effect of cyclophosphamide on Yoshida sarcoma ascites cells implanted into the colon wall of rats.

Authors:  S Bhide; M Habs; H Reinhold; D Schmähl
Journal:  Arzneimittelforschung       Date:  1979

8.  Anticancer activity of new nitrosoureas against Walder carcinosarcoma 256 and DMBA-induced mammary cancer of the rat.

Authors:  H H Fiebig; G Eisenbrand; W J Zeller; R Zentgraf
Journal:  Oncology       Date:  1980       Impact factor: 2.935

9.  Antitumor activity of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-(4-methyl-cyclohexyl)-1-nitrosourea (MeCCNU) on Yoshida sarcoma ascites cells implanted into the colon wall of rats.

Authors:  S Bhide; M Habs; H Reinbold; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1979-05-14       Impact factor: 4.553

10.  Some new congeners of the anticancer agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Synthesis of bifunctional analogs and water soluble derivatives and preliminary evaluation of their chemotherapeutic potential.

Authors:  G Eisenbrand; H H Fiebig; W J Zeller
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1976-08-30
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  3 in total

1.  [Effect of local moderate hyperthermia in combination with chemotherapy by N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) on the descending colon of the rat with transplanted Yoshida sarcoma. 2. Monochemotherapy in combination with subsequent hyperthermia at various time intervals].

Authors:  M Lorenz; E Biwer; M Habs; D Schmähl
Journal:  Langenbecks Arch Chir       Date:  1984

2.  Therapeutic evaluation of five nitrosoureas in a human melanoma xenograft system.

Authors:  R Osieka; P Glatte; R Pannenbäcker; C G Schmidt
Journal:  Cancer Chemother Pharmacol       Date:  1983       Impact factor: 3.333

3.  Chemotherapeutic study on Yoshida sarcoma ascites cells implanted into the glandular stomach of rats. Monotherapy with 5-fluorouracil, methyl-CCNU, mitomycin C, adriamycin, and cytosine arabinoside, and combination therapy with respective two-drug combinations.

Authors:  G Eichler; M Habs; D Schmähl
Journal:  J Cancer Res Clin Oncol       Date:  1983       Impact factor: 4.553
  3 in total

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